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US 2010/0076489 A1Published application
Wound closure material
OwnerJoshua Stopek, Amin Elachchabi +3inventors
InventorsJoshua Stopek, Amin Elachchabi, Roland Ostapoff, Brian Nentwick, Richard Stevenson
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Abstract
Articles are provided having no orientation or a multi-directional orientation. Such articles may be in the form of films, ribbons, sheets, and/or tapes and may be utilized as buttresses with a surgical stapling apparatus or as reinforcing means for suture lines. The articles may be produced with a polymeric material having an agent, such as a chemotherapeutic agent or a radiotherapeutic agent, incorporated therein or applied as a coating thereon.
Claims19
A method comprising:
- obtaining a polymeric material selected from the group consisting of glycolic acid, lactic acid, glycolide, lactide, dioxanone, trimethylene carbonate, caprolactone, and combinations thereof;
- forming the polymeric material into an article that does not possess orientation in a single direction;
- contacting the polymeric material with at least one agent selected from the group consisting of paclitaxel, DHA-paclitaxel, doxetaxel, abraxane, 5-fluorouracil, mitoxantrone, daunorubicin, doxorubicin, cisplatin, carboplatin, methotrexate, bevacizumab, antibody and prodrug conjugates of these, HER-2/neu peptides, proteins, and related vaccines, iodine 125, palladium 103, iridium 192, cesium 131, gold 198, yttrium 90, phosphorus 32, and combinations thereof;
- and
- recovering the article.
2 more elements
Dependencies are inferred from the claim text.