Implantable Device Comprising a Substrate Pre-Coated with Stabilized Fibrin
AssigneeOmrix Biopharmaceuticals Ltd.
InventorsEyal Sheetrit, Israel Nur, Liliana Bar, Lior Weissman
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Abstract
The invention relates to a prosthetic for repairing an opening or a defect in a soft tissue, to its preparation and use. The prosthetic of the invention comprises a substrate viscerally-coated with stabilized and non-completely dry fibrin. The prosthetic displays reduced postoperative complications following its implantation.
Claims20
A method for producing an improved implantable device for repairing an opening or a defect in a soft tissue, the method comprising the steps of:
- providing a substrate having a visceral surface and a non-visceral surface;
- forming a fibrin coating on at least a portion of said visceral surface by applying to said portion a defined volume of a solution comprising fibrinogen and a solution comprising a proteolytic enzyme which is capable of forming fibrin when it reacts with fibrinogen;
- optionally adding a solute capable of binding free water and having a molecular weight of about 1,000 Dalton or less;
- and
- drying the coating,
- thereby obtaining an improved implantable device comprising a stabilized fibrin coating, the device is capable of displaying reduced postoperative complications.
An improved implantable device for repairing an opening or a defect in a soft tissue, the device comprises a substrate having a visceral surface and a non-visceral surface, wherein said visceral surface is at least partially coated with a coating comprising stabilized fibrin, and wherein the fibrin optionally comprises a solute capable of binding free water having a molecular weight of about 1,000 Dalton or less.
Dependencies are inferred from the claim text.