Expandable Member Having A Covering Formed Of A Fibrous Matrix For Intraluminal Drug Delivery

A method of delivering a therapeutic agent into a vessel, the method comprising:

• providing an intraluminal catheter device having,
• an elongated catheter shaft having a proximal end portion and a distal end portion, the shaft having an inflation lumen disposed between the proximal end portion and the distal end portion,
• an expandable member having an outer surface and an inner surface disposed proximate to the distal end portion of the catheter, the expandable member having a therapeutic agent disposed on at least one portion of the outer surface, and
• a covering having a proximal end and a distal end portion positioned over at least one portion of the outer surface of the expandable member, the covering formed of a matrix of fiber elements;
• advancing the catheter device at a desired treatment site;
• and
• introducing fluid into the inflation lumen to expand the expandable member from a first profile to a second profile.

A method of forming an intraluminal catheter device having a covering comprising:

• providing an intraluminal catheter device having an elongated catheter shaft having a proximal end portion and a distal end portion, the shaft having an inflation lumen disposed between the proximal end portion and the distal end portion, an expandable member having an outer surface and an inner surface disposed proximate to the distal end portion of the catheter;
• applying a therapeutic agent to at least one portion of the outer surface of the expandable member;
• and
• positioning a covering having a proximal end and a distal end portion over at least one portion of the expandable member, the covering formed of a matrix of fiber elements.