# US 2010/0076301 A1 · Adaptive imaging parameters with mri

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- Number: US 2010/0076301 A1
- Document ID: US20100076301A1
- Status: Published application
- Kind: A1
- Application number: 12/624,903
- Filed: 2009-11-24
- Published: 2010-03-25
- Earliest claimed: 2005-02-03
- Assignees: Case Western Reserve University
- Inventors: Daniel ELGORT; Eddy WONG; Claudia HILLENBRAND; Jonathan S. LEWIN; Jeffrey L. DUERK
- Web page: https://patentgrep.com/patent/US20100076301A1

## CPC

- G01R 33/54: Signal processing systems, e.g. using pulse sequences {; Generation or control of pulse sequences; Operator console}
- G01R: MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES (indicating correct tuning of resonant circuits H03J3/12)

## Abstract

Systems, methodologies, media, and other embodiments associated with automatically adapting MRI controlling parameters are described. One exemplary method embodiment includes configuring an MRI apparatus to acquire MR signal data using a non-rectilinear trajectory. The example method may also include acquiring MR signals, transforming the MR signals into image data, and selectively adapting the MRI controlling parameters based, at least in part, on information associated with the MR signals.

## Claims

### Claim 1

A system, comprising:
a magnetic resonance imaging (MRI) apparatus configured to acquire a magnetic resonance (MR) signal from an object during an MR procedure using a non-Cartesian trajectory without acquiring information associated with a catheter inserted into the object, the apparatus being controlled, at least in part, by an imaging parameter;
a parameter logic configured to selectively automatically adapt, substantially in real time, the imaging parameter during the MR procedure based, at least in part, on analyzing one or more attributes of the object as provided in data associated with the MR signal without analyzing an attribute of a catheter; and
a data store configured to store the imaging parameter.

### Claim 2 (depends on 1)

The system of claim 1, where the MR procedure is a perfusion MRI procedure, and where the parameter logic is configured to analyze and respond to the data associated with MR signals from the perfusion MRI procedure with respect to one or more of, a contrast change data, a contrast rate of change data, and a contrast saturation data.

### Claim 3 (depends on 1)

The system of claim 1, where the MR procedure is a diffusion MRI procedure, and where the parameter logic is configured to analyze and respond to the data associated with MR signals from the diffusion MRI procedure with respect to one or more of, a water diffusion change data, and a water diffusion rate of change data.

### Claim 4 (depends on 1)

The system of claim 1, where the MR procedure is a BOLD MRI procedure, and where the parameter logic is configured to analyze and respond to the data associated with MR signals from the BOLD MRI procedure with respect to one or more of, a blood oxygen change data, and a blood oxygen rate of change data.

### Claim 5 (depends on 1)

The system of claim 1, where the MR procedure is a perfusion MRI procedure, and where the parameter logic is configured to analyze and respond to the data associated with MR signals from the catheter based MRI procedure with respect to one or more of, a catheter location, a catheter speed, a catheter acceleration, and a catheter orientation.

### Claim 6 (depends on 1)

The system of claim 1, where the non-Cartesian trajectory is one of a two-dimensional spiral imaging sequence, a two-dimensional hybrid imaging sequence, a two-dimensional non-rectilinear k-space trajectory, a three-dimensional radial imaging sequence, a three-dimensional spiral imaging sequence, a three-dimensional hybrid imaging sequence, a rosette trajectory, and a three-dimensional non-rectilinear k-space trajectory.

### Claim 7 (depends on 1)

The system of claim 1, the imaging parameters including one or more of, a temporal resolution parameter, a spatial resolution parameter, a field of view (FOV) parameter, a slice position parameter, a slice orientation parameter, a slice thickness parameter, a slice rotation parameter, a bandwidth parameter, a time to repetition (TR) parameter, a time to echo (TE) parameter, time from inversion (TI) parameter, a signal to noise ratio parameter, a tip angle for the RF excitation parameter, an RF excitation/ADC center frequency parameter, an RF excitation/ADC phase parameter, an active receive coils for data collection parameter, a pulse sequence type parameter, a number of projections per MR signal acquisition period of time parameter, and a number of interleaves per MR signal data acquisition period of time parameter.

### Claim 8 (depends on 1)

The system of claim 1, the MRI apparatus being configured with a phased array of receivers configured to facilitate parallel imaging, the imaging parameters including one or more of, a count of radio frequency channels to employ in parallel imaging, and a count of receivers to employ in parallel imaging.

### Claim 9 (depends on 1)

The system of claim 1, comprising:
a cell manipulation logic configured to control one or more of, delivering a therapeutic agent to a portion of the object, delivering radiation to a portion of the object, heating a portion of the object, freezing a portion of the object, and depriving oxygen to a portion of the object.

### Claim 10

A computer-implemented method, comprising:
establishing a set of configuration data to control an MRI apparatus to acquire MR signals from an object using a non-Cartesian trajectory;
controlling the MRI apparatus to acquire MR signals from the object;
receiving MR signals from the object, where the signals are associated with the object and are not associated with a device inserted into the object;
transforming received MR signals into an image data; and
while continuing to receive MR signals from the object, selectively manipulating the set of configuration data in real time to control the MRI apparatus to acquire MR signals based, at least in part, on a feedback information provided in the MR signals.

### Claim 11 (depends on 10)

The method of claim 10, the MRI apparatus being configured to perform a perfusion MRI and the feedback information including one or more of, a contrast change data, a contrast rate of change data, and a contrast saturation data.

### Claim 12 (depends on 10)

The method of claim 10, the MRI apparatus being configured to perform a diffusion MRI and the feedback information including one or more of, a water diffusion change data, and a water diffusion rate of change data.

### Claim 13 (depends on 10)

The method of claim 10, the MRI apparatus being configured to perform a blood oxygen level dependent (BOLD) MRI and the feedback information including one or more of, a blood oxygen change data, and a blood oxygen rate of change data.

### Claim 14 (depends on 10)

The method of claim 10, the set of configuration data including one or more of, a temporal resolution control value, a spatial resolution control value, a field of view (FOV) control value, a trajectory line count control data, a slice position control value, a slice orientation control value, a slice thickness control value, a slice rotation control value, a bandwidth control value, a time to repetition (TR) control value, a time to echo (TE) control value, a tip angle for the RF excitation control value, a pulse sequence type control value, a number of projections per signal data acquisition period of time control value, a number of interleaves per MR signal data acquisition period of time parameter, a time from inversion (TI) parameter, a signal to noise ratio parameter, an RF excitation/ADC center frequency parameter, an RF excitation/ADC phase parameter, and an active receive coils for data collection parameter.

### Claim 15 (depends on 14)

The method of claim 14, the set of configuration data including data for configuring a phased array of receivers associated with the MRI apparatus to control, at least in part, parallel imaging performed by the MRI apparatus.

### Claim 16 (depends on 10)

The method of claim 10, comprising:
controlling the MRI apparatus to take on a first state based on a first set of configuration data;
beginning a cell manipulating action in a selected tissue region;
acquiring MR signal data from the selected tissue region;
selectively controlling the MRI apparatus to take on a second state based on a second set of configuration data, the second state being different from the first state; and
selectively controlling the cell manipulating action based on information provided in the MR signal data.

### Claim 17 (depends on 16)

The method of claim 16, the cell manipulating action being one of, a delivery of a therapeutic agent, a delivery of radiation, a heating action, a freezing action, and an oxygen deprivation action.