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US 2010/0076283 A1Published application
Particle-containing membrane and particulate electrode for analyte sensors
AssigneeDexCom, Inc.
InventorsPeter C. Simpson, Robert J. Boock, Matthew Wightlin, Mark Shults
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Abstract
Systems and methods of use involving sensors having a particle-containing domain are provided for continuous analyte measurement in a host. In some embodiments, a continuous analyte measurement system is configured to be wholly, transcutaneously, intravascularly or extracorporeally implanted.
Claims20
An analyte detection system for continuous in vivo detection of an analyte, the system comprising:
- a continuous analyte sensor comprising a working electrode configured for implantation in a host, wherein the working electrode comprises an electroactive surface, the continuous analyte sensor further comprising a membrane located over the working electrode, wherein the membrane comprises an enzyme domain and a particle-containing domain, wherein the particle-containing domain comprises a conductive component dispersed in a non-conductive component, wherein the conductive component comprises a plurality of conductive particles, wherein the particle-containing domain is located more distal to the electroactive surface than the enzyme domain, and wherein the particle-containing domain is configured to electrochemically react with at least one interfering species;
- and
- sensor electronics configured to generate a signal associated with an analyte in the host.
A sensor system for measurement of a species in a host, the sensor system comprising:
- an electrode configured for implantation in a host, the electrode comprising an electroactive surface;
- a membrane disposed over the electrode, the membrane comprising a particle-containing domain, wherein the particle-containing domain comprises a sensor element configured to measure a concentration of a species;
- and
- sensor electronics configured to generate a signal associated with a concentration of the species in the host.
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A method for detecting a signal associated with an analyte, the method comprising:
- providing a continuous analyte sensor configured for implantation into a tissue of a host, the continuous analyte sensor comprising a working electrode and a membrane located over the working electrode, wherein the membrane comprises an enzyme domain and a particle-containing domain, wherein the particle-containing domain is located more distal to the working electrode than the enzyme domain;
- electrochemically reacting the particle-containing domain with at least one interfering species;
- and
- detecting a signal from the continuous analyte sensor, wherein the signal is indicative of a concentration of an analyte.
1 more element
Dependencies are inferred from the claim text.