# US 2010/0076223 A1 · Method for producing a beta-alkoxypropionamide

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- Number: US 2010/0076223 A1
- Document ID: US20100076223A1
- Status: Published application
- Kind: A1
- Application number: 12/526,530
- Filed: 2008-01-30
- Published: 2010-03-25
- Earliest claimed: 2007-02-20
- Assignees: Idemitsu Kosan Co., Ltd.
- Inventors: Yasushi Shiraki; Shigeru Matsuo; Toyozo Fujioka
- Web page: https://patentgrep.com/patent/US20100076223A1

## CPC

- C07C 231/02: from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines
- C07C: ACYCLIC OR CARBOCYCLIC COMPOUNDS

## Abstract

A method for producing a β-alkoxypropionamide shown by the following formula (I) including the step of reacting a β-alkoxypropionic acid ester with an amine in the presence of a basic catalyst or in the presence of a basic catalyst and a polyol: wherein R1 is an alkyl group having 1 to 8 carbon atoms, and R2 and R3 are independently hydrogen, a methyl group, an ethyl group, a methoxy group, an ethoxy group, a methoxymethyl group or a glycidyl group.

## Claims

### Claim 1

A method for producing a β-alkoxypropionamide of formula (I) comprising reacting a β-alkoxypropionic acid ester with an amine in the presence of a basic catalyst or in the presence of a basic catalyst and a polyol:
wherein R1 is an alkyl group having 1 to 8 carbon atoms, and R2 and R3 are independently hydrogen, a methyl group, an ethyl group, a methoxy group, an ethoxy group, a methoxymethyl group or a glycidyl group.

### Claim 2 (depends on 1)

The method for producing a β-alkoxypropionamide according to claim 1, further comprising reacting an acrylic acid ester with an aliphatic alcohol in the presence of a basic catalyst to synthesize the β-alkoxypropionic acid ester.

### Claim 3 (depends on 2)

The method for producing a β-alkoxypropionamide according to claim 2, wherein the β-alkoxypropionic acid ester is synthesized from the acrylic acid ester and the aliphatic alcohol by a Michael addition reaction in the presence of the basic catalyst, and subsequently, the β-alkoxypropionic acid ester is reacted with the amine.

### Claim 4 (depends on 3)

The method for producing a β-alkoxypropionamide according to claim 3, wherein the molar ratio of the aliphatic alcohol and the acrylic acid ester (aliphatic alcohol/acrylic acid ester) at the time of charging for the Michael addition reaction is 1.0 to 2.0.

### Claim 5 (depends on 2)

The method for producing a β-alkoxypropionamide according to claim 2, wherein the acrylic ester is a compound of formula (II):
wherein R4 is an alkyl group having 1 to 8 carbon atoms.

### Claim 6 (depends on 2)

The method for producing β-alkoxypropionamide according to claim 2, wherein the aliphatic alcohol is an aliphatic alcohol having 1 to 8 carbon atoms.

### Claim 7 (depends on 1)

The method for producing β-alkoxypropionamide according to claim 1, wherein the amine is a compound of formula (III):
wherein R2 and R3 are independently hydrogen, a methyl group, an ethyl group, a methoxy group, an ethoxy group, a methoxymethyl group or a glycidyl group.

### Claim 8 (depends on 1)

The method for producing a β-alkoxypropionamide according to claim 1, wherein the polyol is ethylene glycol or glycerine.

### Claim 9 (depends on 1)

The method for producing a β-alkoxypropionamide according to claim 1, wherein R1 is an alkyl group having 1 to 6 carbon atoms.