Method for preparation of 6-[3(1-adamantyl) -4-methoxyphenyl]-2-naphtoic acid

A method for preparation of a compound of formula (I)

• wherein:
• R1 is selected from the group consisting of K, Na, Li, H, straight C1-C10alkyl, branched C3-C10alkyl or cyclicC3-C10alkyl and CH2OC1-C5alkyl,
• from a compound of formula (II)
• wherein:
• is Hal is selected from the group consisting of Cl, Br and I,
• by reacting with a compound of formula (III)
• wherein:
• R1 and R2 independently of each other are selected from the group consisting of K, Na, Li, H, aryl, straight C1-C10alkyl, branched C3-C10alkyl and cyclic C3-C10alkyl, or R1 and R2 together form a group (CR4R5)m—(CR6R7)n—, wherein R4, R5, R6 and R7 independently of each other are selected from the group consisting of aryl, H, straight C1-C5alkyl, branched C3-C5alkyl and cyclic C3-C5alkyl;
• and m and n independently of each other are 1 or 2,
• or R1 and R2 together form ortho-substituted aryl,
• R3 is selected from the group consisting of no H and
• in an inert solvent in presence of a basic agent and a catalyst selected from the group consisting of a palladium catalyst, Pd(0) and Pd(0)-phosphine ligand complex, with further reacting the product thus obtained with a compound (IV)
• wherein:
• R9 is selected from the group consisting of K, Na, Li, H, aryl, straight C1-C10alkyl, branched C3-C10alkyl, cyclic C3-C10alkyl, and CH2OC1-C5alkyl;
• Hal is selected from the group consisting Cl, Br and I, in the same reaction mixture, with or without addition of an inorganic base.