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US 2010/0076209 A1Published application
PEG-lipid conjugates for liposomes and drug delivery
OwnerNian Wu, Brian Charles Kellerinventors
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Abstract
New diacylglycerol-polyethylene glycol (DAG-PEG) conjugates are described. A variety of linkers between the PEG chain and glycerol backbone of the DAG-PEGs may be selected to optimize liposomal formulations of pharmaceuticals and cosmetics.
Claims7
A compound represented by the formula
- where R1 has a molecular weight of less than about 215;
- where R2 and R3 are alkyl groups having between 6 and 22 carbons;
- and
- where X is one or more linkers selected from the group consisting of amino, succinylamino, acetamido, aminopentanamido, aminoacetyl, thiopropanoayl, N-(mercaptomethyl)propionamido, mercaptopropylthio)-propanoyl, (1,2-dihydroxy-3-mercaptopropylthio)propanoyl, succinyl, acetyl, oxopentanoyl, carbamoyl, aminoalkyl, glutaramido, aminoethanethiol, mercaptopropanol, (hydroxypropylthio)propanoayl, 3-((2-propionamidoethyl)disulfanyl)propanoayl, (((acetamidoethyl)disulfanyl)propanoyloxy)glutaramido, aminoethanethioate, and 2-hydroxyacetic proprionic anhydride.
1 more element
Dependencies are inferred from the claim text.