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AssigneeMassachusetts Institute of Technology
InventorsGregory Stephanopoulos, Christopher R. Loose, Kyle Jensen
Estimating the term…
Antimicrobial peptides are small proteins used by the innate immune system to combat bacterial infection in multicellular eukaryotes. There is mounting evidence that these peptides are less susceptible to bacterial resistance than traditional antibiotics and that they may form the basis for a novel class of therapeutics. Systems and methods may treat the amino acid sequences of these peptides as a formal language and build a set of right-linear grammars that describe this language. These grammars may allow for rationally designed novel antimicrobial peptides in silico. These peptides conform to the syntax of natural antimicrobial peptides lack significant homology to any natural sequences, thus populating a previously unexplored region of protein sequence space. Synthesis of these peptides, leads to de novo AmPs.
-20. (canceled)
An antimicrobial peptide produced by a method comprising the steps of
The antimicrobial peptide according to claim 1, wherein the step of correlating the set of patterns with the randomly generated sequences includes processing a sequence to determine a score representative of a percentage of the sequence that matches to a pattern in the set of patterns, wherein the percentage is 90%.
The antimicrobial peptide according to claim 1, wherein the step of mutating a sequence includes a substitution process wherein substitution among similar entities is preferred.
The antimicrobial peptide according to claim 1, wherein the step of determining a set of patterns includes identifying a set of patterns in a data set of biological sequences having antimicrobial activity.
The antimicrobial peptide according to claim 1, further comprising the step of determining a second set of patterns being representative of a peptide having a second characteristic of interest, and correlating the mutated peptide sequences with the second set of patterns to identify peptide sequences having the first characteristic and the second characteristic of interest.
The antimicrobial peptide of claim 1, further comprising the step of synthesizing a peptide having substantially the selected mutated peptide sequence.
Dependencies are inferred from the claim text.