Biodegradable nitric oxide generating polymers and related biomedical devices
AssigneeNorthwestern University
InventorsGuillermo Ameer, Melina Kibbe, Haichao Zhao
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Abstract
Disclosed herein is a biodegradable nitric oxide-generating polymer comprising a nitric oxide-releasing N2O2− (NONOate) functional group. The polymer can be applied to various medical devices for the treatment of various diseases such as thrombosis and restenosis.
Claims16
A biocompatible elastomeric polymer selected from
- a) a compound having a formula
- wherein R is hydrogen or a polymer, each A is independently selected from a NONOate-containing amine diol unit and an aliphatic diol unit, and n is an integer greater than 1, provided that at least one each of NONOate-containing amine diol unit and an aliphatic diol unit is present;
- and
- b) an amine-crosslinked elastomer of a citric acid-aliphatic diol pre-polymer.
A method of preparing an amine crosslinkable elastomer of a citric acid aliphatic diol pre-polymer comprising:
- a) synthesizing a prepolymer of citric acid and aliphatic diol;
- b) post-polymerizing the prepolymer with a crosslinkable amine unit;
- and
- c) reacting the post-polymer with NO gas.
A method of preparing a biocompatible elastomeric polymer of the formula
- wherein R is hydrogen or a polymer, each A is independently selected from a NONOate-containing amine diol unit and an aliphatic diol unit, and n is an integer greater than 1, provided that at least one each of NONOate-containing amine diol unit and an aliphatic diol unit is present, comprising:
- a) polycondensing a citric acid, an aliphatic diol and an amino diol;
- b) crosslinking;
- and
- c) treating the crosslinked polymer with NO gas.
A biomedical device wherein at least one surface of the device has deposited thereon a coating comprising a NO-releasing elastomer selected from a) a compound having formula
- wherein R is hydrogen or a polymer, each A is independently selected from a NONOate-containing amine diol unit and an aliphatic diol unit, and n is an integer greater than 1, provided that at least one each of NONOate-containing amine diol unit and an aliphatic diol unit is present;
- and
- b) an amine crosslinkable elastomer of a citric acid-aliphatic diol pre-polymer.
Dependencies are inferred from the claim text.