Process for the preparation of o-desmethyl venlafaxine
AssigneeMerck Development Centre Private Limited Plot 1 A/2
InventorVinayak G. Gore
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Abstract
The present invention relates to a novel process for the preparation of O-desmethyl venlafaxine (ODV).
Claims25
A process for the preparation of acetamide (VII), comprising reacting acid (VI) with thionyl chloride and dimethylamine or a salt thereof, wherein the group X is any group capable of being converted into a hydroxyl group:
A process for the preparation of amido cyclohexanol (VIII), comprising reacting acetamide (VII) with a base and cyclohexanone, wherein the group X is any group capable of being converted into a hydroxyl group:
A process for the preparation of amino cyclohexanol (IX), comprising reducing amido cyclohexanol (VIII) with a reducing agent, wherein the group X is any group capable of being converted into a hydroxyl group:
A process for the preparation of O-desmethylvenlafaxine (I) or a pharmaceutically acceptable salt thereof, wherein the process comprises:
- reacting acid (VI) with dimethylamine or a salt thereof to form acetamide (VII):
- reacting acetamide (VII) with a base and cyclohexanone to form amido cyclohexanol (VIII):
- reducing amido cyclohexanol (VIII) with a reducing agent to form amino cyclohexanol (IX):
- wherein the group X is any group capable of being converted into a hydroxyl group.
Dependencies are inferred from the claim text.