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US 2010/0076067 A1Published application
Biodegradable block copolymeric compositions for drug delivery
OwnerChung Shih, Gaylen M. Zentnerinventors
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Abstract
An improved drug delivery composition and method of use is disclosed. The composition comprises one or more biodegradable block copolymer drug carriers; and a reconstitution enhancing and enabling agent comprising polyethylene glycol (PEG), a PEG derivative or a mixture of PEG and a PEG derivative. The composition can be administered as is or after being be dissolved or rapidly reconstituted in an aqueous vehicle to afford a homogeneous solution or uniform colloidal systems.
Claims25
1-34. (canceled)
A method of preparing an improved drug delivery formulation comprising the steps of:
- A) providing a drug delivery composition comprising
- (i) one or more biodegradable block copolymer drug carriers comprising A-B, A-B-A or B-A-B block copolymers having a total weight average molecular weight of 1000 to 100,000 Daltons, wherein the A block is a biodegradable polyester or poly(ortho ester) and the B block is polyethylene glycol(PEG), and the weight percentage of the A block is between 20 to 99% and the weight percentage of the B block is between 1 to 80%, wherein said block copolymer, when formed as an aqueous polymer solution, remains a free flowing liquid upon parenteral administration;
- and
- (ii) a liquid polyethylene glycol(PEG), a PEG derivative, or a mixture of PEG and a PEG derivative, said PEG or PEG derivative having a molecular weight of 150 to 1100 Daltons;
- and wherein the biodegradable block copolymeric drug carriers is soluble in the liquid PEG, PEG derivatives, or mixtures of PEG and PEG derivatives;
- and wherein the weight ratio of the biodegradable block copolymeric drug carrier and the PEG, PEG derivative or mixtures thereof is within the range of 5:1 to 1:99, and
- B) formulating the composition as an injectable liquid which is without water, or mixing the water or mixing an aqueous solution with the composition to form a homogeneous aqueous solution or a uniform colloidal system.
4 more elements
A method of preparing an improved drug delivery formulation comprising the steps of:
- A) providing a drug delivery composition comprising
- (i) one or more biodegradable block copolymer drug carriers comprising A-B. A-B-A or B-A-B block copolymers having a total weight average molecular weight of 2000 to 8000 Daltons, wherein the A block is a biodegradable polyester or poly(ortho ester) and the B block is polyethylene glycol(PEG), and the weight percentage of the A block is between 50.1% to 83% and the weight percentage of the B block is between 17% to 49.9%, wherein said block copolymer, when formed as an aqueous polymer solution, remains a free flowing liquid upon parenteral administration;
- and
- (ii) a polyethylene glycol(PEG), a PEG derivative, or a mixture of PEG and a PEG derivative, said PEG or PEG derivative having a molecular weight of 150 to 1100 Daltons;
- and wherein at least one of the biodegradable block copolymeric drug carriers is soluble in an aqueous solution and miscible with the PEG, PEG derivatives, or mixtures thereof, and wherein the weight ratio of the biodegradable block copolymeric drug carrier and the PEG. PEG derivative or mixtures thereof is within the range of 5:1 to 1:99;
- and
- B) formulating the composition as an injectable liquid which is without water, or mixing water or mixing an aqueous solution with the composition to form a homogeneous aqueous solution or a uniform colloidal system.
4 more elements
A method of preparing an improved drug delivery formulation comprising the steps of:
- A) providing a drug delivery composition comprising
- (i) one or more biodegradable block copolymer drug carriers comprising A-B, A-B-A or B-A-B block copolymers having a total weight average molecular weight of 1000 to 100,000 Daltons, wherein the A block is a biodegradable polyester or poly(ortho ester) and the B block is polyethylene glycol(PEG), and the weight percentage of the A block is between 20 to 99% and the weight percentage of the B block is between 1 to 80%, wherein said block copolymer, when formed as an aqueous polymer solution, remains a free flowing liquid upon parenteral administration;
- and
- (ii) a liquid polyethylene glycol(PEG), a PEG derivative, or a mixture of PEG and a PEG derivative, said PEG or PEG derivative having a molecular weight of 150 to 1100 Daltons;
- and wherein the biodegradable block copolymeric drug carriers is soluble in the liquid PEG. PEG derivatives, or mixtures of PEG and PEG derivatives, and wherein the weight ratio of the biodegradable block copolymeric drug carrier and the PEG, PEG derivative or mixtures thereof is within the range of 5:1 to 1:99;
- and
- B) formulating the composition as an injectable liquid without adding water.
4 more elements
Dependencies are inferred from the claim text.