Methods for identifying analgesic agents
AssigneeXenon Pharmaceuticals Inc.
InventorsMarcia I. MacDonald, Mark E. Samuels, Robin Sherrington, Yigal P. Goldberg
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Abstract
The present invention relates to the discovery that mutations in SCN9A are causative of Congenital Indifference to Pain (CIP) in humans. The invention also relates to methods of utilizing the SCN9A gene and expression products thereof for the screening and identification of therapeutic agents, including small organic compounds, which are selective for SCN9A, and are useful in the treatment of pain and other disorders. The invention also relates to methods of using these compounds to treat or otherwise ameliorate such disorders.
Claims19
1-38. (canceled)
A method for treating a mammal afflicted with a condition related to sodium channel activity, comprising administering to said mammal an effective amount of an agent that selectively decreases SCN9A-mediated ion flux activity in said mammal.
Dependencies are inferred from the claim text.