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US 2010/0076048 A1Published application
Isoindol Derivatives As EP4 Receptor Agonists
OwnerGerard Martin Paul Giblin, Mark Patrick Healyinventors
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Abstract
The present invention relates to indole derivatives, to processes for their preparation, to pharmaceutical compositions containing them and to their use in medicine.
Claims8
A compound selected from the group consisting of:
- {4-[4,9-Bis(ethyloxy)-1,3-dioxo-1,3-dihydro-2H-benzo[f]isoindol-2-yl]-3-chlorophenyl}acetic acid;
- {3-Chloro-4-[1,3-dioxo-4,9-bis(propyloxy)-1,3-dihydro-2H-benzo[f]isoindol-2-yl]phenyl}acetic acid;
- (4-{4,9-Bis(1-methylethoxy)-1,3-dioxo-1,3-dihydro-2H-benzo[f]isoindol-2-yl}-3-chlorophenyl)acetic acid;
- {4-[4,9-Bis(ethyloxy)-1,3-dioxo-1,3-dihydro-2H-benzo[f]isoindol-2-yl]-3-bromophenyl}acetic acid;
- {3-Bromo-4-[1,3-dioxo-4,9-bis(propyloxy)-1,3-dihydro-2H-benzo[f]isoindol-2-yl]phenyl}acetic acid;
- (4-{4,9-Bis(1-methylethoxy)-1,3-dioxo-1,3-dihydro-2H-benzo[f]isoindol-2-yl}-3-bromophenyl)acetic acid;
- (4-{4,9-Bis(1-methylethoxy)-1-oxo-1,3-dihydro-2H-benzo[f]isoindol-2-yl}-3-chlorophenyl)acetic acid;
- {3-Chloro-4-[1-oxo-4,9-bis(propyloxy)-1,3-dihydro-2H-benzo[f]isoindol-2-yl]phenyl}acetic acid;
- {3-Bromo-4-[1-oxo-4,9-bis(propyloxy)-1,3-dihydro-2H-benzo[f]isoindol-2-yl]phenyl}acetic acid;
- (4-{4,9-Bis(1-methylethoxy)-1-oxo-1,3-dihydro-2H-benzo[f]isoindol-2-yl}-3-bromophenyl)acetic acid;
- and salts thereof.
8 more elements
6-7. (canceled)
Dependencies are inferred from the claim text.