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US 2010/0076045 A1Published application
Stabilized pharmaceutical sub-micron suspensions and methods of forming same
OwnerErnesto J. Castillo, Bahram Asgharian +1inventors
InventorsErnesto J. Castillo, Bahram Asgharian, Masood A. Chowhan
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Abstract
The present invention is directed to a pharmaceutical submicron suspension and a method of forming the submicron suspension. The submicron suspension is useful for delivery of relatively hydrophobic and/or low solubility therapeutic agent. The submicron suspension and method of forming the submicron suspension typically employ a polymeric material that aids in preventing aggregation of the therapeutic agent.
Claims20
A pharmaceutical submicron suspension, comprising:
- a hydrophobic therapeutic agent that is formed of submicron particles;
- a polymeric material that includes low molecular weight charged polymer;
- and
- one or more excipients, wherein
- i) the low molecular weight charged polymer inhibits the aggregation of the submicron particles within the suspension;
- and
- ii) the submicron particles have an average or mean hydrodynamic radius that is less than 1 micron.
4 more elements
A method of forming a pharmaceutical submicron suspension, the method comprising:
- providing a hydrophobic therapeutic agent in the form of particles wherein the particles have an average or mean hydrodynamic radius of at least 1 micron;
- combining the particles of therapeutic agent with a polymeric material to form an admixture, the polymeric material including low molecular weight charged polymer;
- processing the admixture to transform the particles of therapeutic agent into submicron particles of the therapeutic agent, the submicron particles of therapeutic agent having an average or mean hydrodynamic radius of less than 900 nanometers;
- and
- combining the admixture with one or more excipients thereby forming the pharmaceutical submicron suspension wherein the low molecular weight charged polymer inhibits the aggregation of the particles and submicron particles during the processing or upon formation of the suspension.
2 more elements
Dependencies are inferred from the claim text.