Indole- and benzimidazole amides as hydroxysteroid dehydrogenase inhibitors

A compound of the formula I:

• wherein:
• X is selected from CR5 and N;
• R1 is selected from H and C1-C6alkyl-R6, wherein the alkyl group is substituted with 0-3 R7;
• R2 is selected from hydrogen, halo, C1-C6alkyl, and —C(═O)R13;
• alternatively, R1 and R2 are, independently,
• Ring A is a saturated or partially saturated bicyclic or tricyclic ring consisting of the shown nitrogen, 4-10 carbon atoms, and 0-2 additional heteroatoms selected from nitrogen, oxygen, and sulphur;
• Ring A is substituted with 0-3 groups selected from C1-C8alkyl, halo, hydroxy, oxo, cyano, C1-C6alkyloxy, C1-C6alkyloxyC1-C6alkylene, and C1-C6alkylcarbonyl, wherein each alkyl/alkylene group is substituted with 0-3 R14;
• R5 is selected from hydrogen, C1-C6alkyl, —C(═O)R13, and cyano;
• R6 is selected from cyano, C3-C10cycloalkyl, 3-10 membered hetcycloalkyl, aryl, hetaryl, —C(═O)R13, —S(═O)nR13, —S(═O)nNR18R19, —N(R18)S(═O)nR13, —N(R23)C(═Y)NR18R19, —C(═NR15)NR15, —N(R18)C(═O)R13, —N(R18)C(═O)—C3-C10cycloalkyl, —N(R18)C(═O)-3-10 membered hetcycloalkyl, —N(R18)C(═O)-aryl, —N(R18)C(═O)-hetaryl, wherein the cycloalkyl, hetcycloalkyl, aryl, and hetaryl groups are substituted with 0-3 R16;
• R7 is selected from halo, hydroxy, oxo, cyano, and C1-C8alkyl;
• R8, R9, R10 and R11 are each independently selected from hydrogen, C1-C8alkyl, F, trihalomethyl, trihalomethoxy, hydroxy, and C1-C6alkyloxy, wherein the C1-C8alkyl and C1-C6alkyloxy are substituted with 0-3 R17;
• alternatively, R8 and R9 together with the carbon atom to which they are attached form a saturated or partially saturated ring consisting of the carbon atom shown, 2-5 additional carbon atoms, and 0-2 heteroatoms selected from nitrogen, oxygen, and sulphur, wherein this ring is substituted with 0-3 groups selected from halo, trihalomethyl, C1-C6alkyl, aryl, hetaryl, arylC1-C6alkylene, hetarylC1-C6-alkylene, hydroxy, oxo, C1-C6alkyloxy, aryloxy, arylC1-C6alkyloxy or hetarylC1-C6alkyloxy;
• alternatively, R10 and R11 together with the carbon atom to which they are attached form a saturated or partially saturated ring consisting of the carbon atom shown, 2-5 additional carbon atoms, and 0-2 heteroatoms selected from nitrogen, oxygen, and sulphur, wherein this ring is substituted with 0-3 groups selected from halo, trihalomethyl, C1-C6alkyl, aryl, hetaryl, arylC1-C6alkylene, hetarylC1-C6-alkylene, hydroxy, oxo, C1-C6alkyloxy, aryloxy, arylC1-C6alkyloxy or hetarylC1-C6alkyloxy;
• alternatively, R8 and R10 together with the two carbon atoms to which they are attached form a saturated or partially saturated ring consisting of the two shown carbon atoms, 1-4 additional carbon atoms, and 0-2 heteroatoms selected from nitrogen, oxygen, and sulphur, wherein this ring is substituted with 0-3 groups selected from halo, trihalomethyl, C1-C6alkyl, aryl, hetaryl, arylC1-C6alkylene, hetarylC1-C6alkylene, hydroxy, oxo, C1-C6alkyloxy, aryloxy, arylC1-C6alkyloxy, and hetarylC1-C6alkyloxy;
• R12 is selected from H, OH, NR18R19, C3-C10cycloalkyl, 3-10 membered hetcycloalkyl, —C(═O)R13, —S(═O)nR13, S(═O)nNR18R19, —N(R18)S(═O)nR13, and —C(═NR15)NR16;
• wherein the cycloalkyl and hetcycloalkyl groups are substituted with 0-3 R17;
• R13 is selected from OH, C1-C8alkyl, C1-C8alkyloxy, C1-C8alkyloxyC1-C4alkylene, aryl, hetaryl, aryloxy, hetaryloxy, and NR18R19;
• R14 is selected from halo, hydroxy, oxo, and cyano;
• R15 and R16 are independently selected from H, C1-C8alkyl, 3-10 membered cycloalkyl, halo, OH, cyano, —C(═O)R13, —S(═O)nR13, S(═O)nNR18R19, —N(R18)S(═O)nR13, aryl, and hetaryl, wherein the alkyl and cycloalkyl groups are substituted with 0-3 R20;
• R17 is selected from halo, OH, oxo, nitro, cyano, —C(═O)R13, —S(═O)nR13, S(═O)nNR18R19, —N(R18)S(═O)nR13, NR18R19, C1-C8alkyl, C1-C6alkyloxy, and aryloxy;
• R18 and R19 are independently selected from H, C1-C8alkyl, C1-C8alkyloxy, aryl, hetaryl, arylC1-C6alkylene, and hetarylC1-C6alkylene, wherein the alkyl/alkylene, aryl, and hetaryl groups are independently substituted with 0-3 R20;
• alternatively, R18 and R19, together with the nitrogen atom to which they are attached, form a saturated or partially saturated monocyclic, bicyclic, or tricyclic ring consisting of the shown nitrogen, 4-10 carbon atoms, and 0-2 additional heteroatoms selected from nitrogen, oxygen, and sulfur, wherein this ring is substituted with 0-3 C1-C8alkyl, aryl, hetaryl, arylC1-C6alkylene, hetarylC1-C6alkylene, hydroxy, oxo, C1-C6alkyloxy, arylC1-C6alkyloxy, hetarylC1-C6alkyloxy, C1-C6alkyloxyC1-C6alkyl, C1-C6alkylcarbonyl, arylcarbonyl, hetarylcarbonyl, arylC1-C6alkylcarbonyl, hetarylC1-C6alkylcarbonyl, C1-C6alkylcarboxy, arylcarboxy, hetarylcarboxy, arylC1-C6alkyl-carboxy, and hetarylC1-C6alkylcarboxy;
• R20 is selected from H, OH, oxo, halo, cyano, nitro, C1-C6alkyl, C1-C6alkyloxy, NR21R22, methylendioxo, dihalomethylendioxo, trihalomethyl, and trihalomethyloxy;
• R21 and R22 are independently selected from H, C1-C8alkyl, and arylC1-C6alkyl;
• R23 is selected from H and C1-C6alkyl;
• n is selected from 0, 1, and 2;
• Y is selected from O and S;
• or a salt thereof with a pharmaceutically acceptable acid or base, or any optical isomer or mixture of optical isomers, including a racemic mixture, or any tautomeric forms.