Therapeutic agent for urinary excretion disorder
AssigneeOno Pharmaceutical Co., Ltd.
InventorsTakayuki Maruyama, Hiroki Okada, Takashi Konemura
Life of this patent
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Abstract
Disclosed is an EP1 antagonist, particularly a compound represented by the formula (I): wherein all symbols are as defined in the description, a salt thereof, a solvate thereof or a prodrug thereof. The compound, a salt thereof, a solvate thereof or a prodrug thereof is effective for prevention, treatment and/or symptom improvement of a dysuria (e.g., slow stream, splitting or spraying of the urine stream, intermittent stream, hesitancy, straining to void or terminal dribble).
Claims13
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A method for prevention, treatment and/or symptom improvement of a dysuria, which comprises administering an effective amount of a compound represented by the formula (I):
- wherein R1 represents —COOR1-1 wherein R1-1 represents a hydrogen atom or C1-6 alkyl, 5-tetrazolyl, 5-oxo-1,2,4-oxadiazolyl, —CH2OH or 5-oxo-1,2,4-thiadiazolyl;
- R2 represents a hydrogen atom, methyl, methoxy or chloro;
- R3 and R4 represent a combination of (1) methyl and methyl, (2) methyl and chloro, (3) chloro and methyl or (4) trifluoromethyl and a hydrogen atom or
- R3 and R4 form (5) cyclopentene, (6) cyclohexene or (7) a benzene ring together with the carbon atom to which they bind;
- R5 represents isopropyl, isobutyl, 2-methyl-2-propenyl, cyclopropylmethyl, methyl, ethyl, propyl, 2-propenyl or 2-hydroxy-2-methylpropyl;
- Ar represents thiazolyl optionally substituted by methyl residue, pyridyl or 5-methyl-2-furyl;
- n is 0 or 1 wherein n is 0 in cases where R1 is 5-tetrazolyl, 5-oxo-1,2,4-oxadiazolyl or 5-oxo-1,2,4-thiadiazolyl,
- a salt thereof, a solvate thereof or a prodrug thereof to a mammal.
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A medicament comprising a combination of a compound represented by the formula (I), a salt thereof, a solvate thereof or a prodrug thereof and an α1 receptor antagonist and/or an acetylcholinesterase inhibitor.
Dependencies are inferred from the claim text.