Transdermal Drug Delivery using an Osmolyte and Vasoactive Agent
AssigneeBioChemics, Inc.
InventorsStephen G. Carter, Zhen Zhu, Kanu Patel, John J. Masiz
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Abstract
A formulation and method for delivery of bioactive substances when applied to, or within, the skin or other exterior region of a mammal. for example, a patient, includes a vasoactive agent; an osmolyte; and an active ingredient. The formulation is sufficiently hygroscopic so as to create a condition of hypertonicity when absorbed by the skin. When the formulation is applied to the skin, the vasoactive agent can be delivered to the dermis so as to contact the vasculature of a patient.
Claims39
A formulation for topical delivery of an active ingredient to a mammal, said mammal having a body surface and said body surface comprising a dermis and a topical application site, the formulation comprising:
- a vasoactive agent capable of penetrating said dermis;
- an osmolyte;
- and
- an active ingredient,
- the formulation being sufficiently hygroscopic to create a condition of hypertonicity local to said topical application site.
A method for enhancing the penetration of an active ingredient into or through the body surface, the method comprising introducing the active ingredient with a vasoactive agent and an osmolyte into or onto a region of the body surface so as to cause the active agent to cross the basement membrane.
A method for topical delivery of an active ingredient to a mammal, said mammal having a body surface and said body surface comprising a dermis and a topical application site, the method comprising:
- administering a vasoactive agent to the topical application site, said vasoactive agent being deliverable to a region of said dermis;
- administering an amount of osmolyte to the topical application, said amount being sufficient to create a condition of hypertonicity when absorbed at the application site;
- and
- administering an active ingredient to the topical application site.
A method of manufacturing a medicament for transdermal administration, the method comprising combining a vasoactive agent;
- an osmolyte;
- and an active ingredient in sufficient amounts to cause permeation of the active ingredient to at least one affected region of a mammal when applied to a body surface of the mammal.
Dependencies are inferred from the claim text.