3-amino-indazole or 3-amino-4,5,6,7-tetrahydro-indazole derivatives

A compound of the formula:

• or a pharmaceutically acceptable salt thereof, wherein:
• R1 is a ring selected from the group consisting of phenyl, naphthyl and heteroaryl, said ring being unsubstituted or substituted with 1 to 3 substituents independently selected from the group consisting of:
• (1) lower alkyl, (2) halogen, (3) lower halogenalkyl, (4) hydroxy, (5) lower alkoxy, (6) lower halogenalkoxy and (7) cyano;
• R2, R3, R4 and R5 independently from each other are selected from the group consisting of hydrogen, halogen and lower alkyl;
• R2′ and R3′ together as well as R4′ and R5′ together are replaced by a double bond, or R2′, R3′, R4′ and R5′ are hydrogen;
• R6 is selected from the group consisting of:
• (1) lower alkyl,
• (2) cycloalkyl,
• (3) lower alkoxyalkyl,
• (4) unsubstituted phenyl or phenyl substituted with 1 to 3 substituents independently selected from the group consisting of lower alkyl, halogen, lower halogenalkyl, hydroxy, lower alkoxy, lower halogenalkoxy, carboxyl, lower alkoxycarbonyl, lower alkoxycarbonylalkyl, lower carboxylalkoxy, lower alkoxycarbonylalkoxy and cyano,
• (5) lower phenylalkyl, wherein the phenyl group is unsubstituted or substituted with 1 to 3 substituents independently selected from the group consisting of lower alkyl, halogen, lower halogenalkyl, hydroxy, lower alkoxy, lower halogenalkoxy and cyano,
• (6) heterocyclyl, and
• (7) unsubstituted heteroaryl or heteroaryl substituted with 1 to 3 substituents independently selected from the group consisting of lower alkyl, halogen, lower halogenalkyl, hydroxy, lower alkoxy, lower halogenalkoxy and cyano;
• R7 is selected from the group consisting of (1) hydrogen, (2) —C(O)—NH—R8, (3) —C(O)—R9, (4) —S(O)2—R10, and (5) —C(O)—OR11;
• R8 is selected from the group consisting of:
• (1) lower alkyl,
• (2) cycloalkyl,
• (3) lower cycloalkylalkyl,
• (4) cycloalkyl substituted by hydroxy, carboxyl, tetrazolyl or lower carboxylalkyl,
• (5) heterocyclyl, and
• (6) unsubstituted phenyl or phenyl substituted with 1 to 3 substituents independently selected from the group consisting of lower alkyl, halogen, lower halogenalkyl, hydroxy, lower alkoxy, lower halogenalkoxy, carboxyl, tetrazolyl, lower alkoxycarbonyl, lower alkoxycarbonylalkyl, lower carboxylalkyl, lower carboxylalkoxy, lower alkoxycarbonylalkoxy, cyano and cycloalkyloxy wherein the cycloalkyl group of said cycloalkyloxy is substituted by carboxyl;
• R9 is selected from the group consisting of:
• (1) lower alkyl,
• (2) cycloalkyl,
• (3) lower cycloalkylalkyl, and
• (4) lower phenylalkyl, wherein the phenyl group of said lower phenylalkyl is unsubstituted or substituted with 1 to 3 substituents independently selected from the group consisting of lower alkyl, halogen, lower halogenalkyl, hydroxy, lower alkoxy, lower halogenalkoxy, carboxyl, tetrazolyl, lower alkoxycarbonyl, lower alkoxycarbonylalkyl, lower carboxylalkyl, lower carboxylalkoxy, lower alkoxycarbonylalkoxy, cyano and cycloalkyloxy wherein the cycloalkyl group of said cycloalkyloxy is substituted by carboxyl;
• R10 is selected from the group consisting of:
• (1) lower alkyl,
• (2) cycloalkyl,
• (3) lower cycloalkylalkyl, and
• (4) lower phenylalkyl, wherein the phenyl is unsubstituted or substituted with 1 to 3 substituents independently selected from the group consisting of lower alkyl, halogen, lower halogenalkyl, hydroxy, lower alkoxy, lower halogenalkoxy, carboxyl, tetrazolyl, lower alkoxycarbonyl, lower alkoxycarbonylalkyl, lower carboxylalkyl, lower carboxylalkoxy, lower alkoxycarbonylalkoxy, cyano and cycloalkyloxy wherein the cycloalkyl group of said cycloalkyloxy is substituted by carboxyl;
• and
• R11 is selected from the group consisting of:
• (1) lower alkyl,
• (2) cycloalkyl,
• (3) lower cycloalkylalkyl,
• (4) cycloalkyl substituted by hydroxy, carboxyl, tetrazolyl or lower carboxylalkyl,
• (5) heterocyclyl, and
• (6) unsubstituted phenyl and phenyl substituted with 1 to 3 substituents independently selected from the group consisting of lower alkyl, halogen, lower halogenalkyl, hydroxy, lower alkoxy, lower halogenalkoxy, carboxyl, tetrazolyl, lower alkoxycarbonyl, lower alkoxycarbonylalkyl, lower carboxylalkyl, lower carboxylalkoxy, lower alkoxycarbonylalkoxy, cyano and cycloalkyloxy wherein the cycloalkyl group of said cycloalkyloxy is substituted by carboxyl.