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US 2010/0076023 A1Published application
Amorphous solid composition containing a pyrazole-3-carboxamide in amorphous form and stabilising carriers
AssigneeSanofi-Aventis
InventorsJean Alié, Jérome MENEGOTTO, Michel BAUER
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Abstract
The invention relates to a pyrazole-3-carboxamide in amorphous form, to an amorphous solid solution containing the same, and more generally to pharmaceutical composition containing the same
Claims24
A pyrazole-3-carboxamide derivative in amorphous form, selected from:
- N-piperidino-5-(4-bromophenyl)-1-(2,4-dichlorophenyl)-4-ethylpyrazole-3-carboxamide, which exhibits a glass transition temperature of between 60° C. and 90° C., and in that its X-ray diffractogram shows the presence of a halo and the absence of diffraction peaks;
- and
- N-piperidino-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methylpyrazole-3-carboxamide, which exhibits a glass transition temperature of between 65° C. and 95° C., and in that its X-ray diffractogram shows the presence of a halo and the absence of diffraction peaks.
An amorphous solid solution comprising a pyrazole-3-carboxamide derivative selected from:
- N-piperidino-5-(4-bromophenyl)-1-(2,4-dichlorophenyl)-4-ethylpyrazole-3-carboxamide;
- and
- N-piperidino-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methylpyrazole-3-carboxamide;
- or a salt thereof in amorphous form;
- and
- one or more excipients themselves in amorphous form.
3 more elements
Dependencies are inferred from the claim text.