Aminopyridine Derivatives

A compound of formula (I):

• wherein:
• R1 and R2 are independently selected from H, OH, (C1-C10)alkyl, (C1-C6)alkoxy, (C2-C6)alkenyl, (C3-C10)cycloalkyl, heterocycloalkyl, aryl, heteroaryl, aryl(C1-C4)alkyl- and heteroaryl(C1-C4)alkyl-;
• R3 is selected from H, (C1-C10)alkyl and (C2-C6)alkenyl;
• R4 and R5 are selected from H, (C1-C10)alkyl, (C2-C6)alkenyl, (C3-C10)cycloalkyl, heterocycloalkyl, aryl, heteroaryl, aryl(C1-C4)alkyl- and heteroaryl(C1-C4)alkyl-;
• R6 and R7 are selected from H, (C1-C10)alkyl, (C2-C6)alkenyl, (C3-C10)cycloalkyl, heterocycloalkyl, aryl, heteroaryl, aryl(C1-C4)alkyl-, aryl(C2-C4)alkenyl-, heteroaryl(C1-C4)alkyl-, —SO2(C1-C6)alkyl, —SO2aryl and —SO2arylC1-C4)alkyl;
• or R6 and R7 together with the nitrogen atom to which they are attached may form a 4-7 membered N-containing ring, optionally containing one further heteroatom selected from N, O and S, and optionally substituted with 1 or 2 substituents independently selected from (C1-C6)alkyl, (C1-C6)alkoxy, halo, CN and hydroxyl, said N-containing ring may also optionally be fused to an aryl group;
• or R4 and R6 together with the atoms to which they are attached may form a saturated or partially unsaturated 4-7 membered N-containing ring, optionally containing one further heteroatom selected from N, O and S, and optionally substituted on carbon with 1 or 2 substituents independently selected from (C1-C6)alkyl, (C1-C6)alkoxy, halo, CN and hydroxyl;
• or R5 is absent and R4 and R6 together with the atoms to which they are attached may form a 5, 6, 9 or 10 membered mono- or bi-cyclic N-containing aromatic ring, optionally containing one further heteroatom selected from N, O and S, and optionally substituted on carbon with 1, 2 or 3 substituents independently selected from (C1-C6)alkyl, (C1-C6)alkoxy, halo, CN, aryl, COOR14 and hydroxyl;
• or R4 and R6 may together form a group according to formula II or formula III:
• R8, R9 and R10 are independently selected from H, (C1-C10)alkyl, halo, hydroxyl and (C1-C6)alkoxy;
• R11 is selected from H and (C1-C6)alkyl;
• R12 is selected from H and (C1-C6)alkyl;
• R13 is selected from H, (C1-C6)alkyl, (C1-C6)alkoxy, OH, CN, CF3, COOR14, halo and NR14R15;
• R14 and R15 are independently selected from H and (C1-C6)alkyl;
• f and g are independently selected from 0, 1, 2 and 3, such that f+g=1, 2 or 3;
• h is selected from 1 and 2;
• wherein:
• alkyl may optionally be substituted with 1 or 2 substituents independently selected from (C3-C10)cycloalkyl, (C1-C6)alkoxy, OH, CN, CF3, COOR14, halo and NR14R15;
• alkenyl may optionally be substituted with 1 or 2 substituents independently selected from (C3-C10)cycloalkyl, (C1-C6)alkoxy, OH, CN, CF3, COOR14, halo and NR14R15;
• alkoxy may optionally be substituted with 1 or 2 substituents independently selected from (C3-C10)cycloalkyl, OH, CN, CF3, COOR14, halo and NR14R15;
• cycloalkyl is a non-aromatic mono- or bi-cylic hydrocarbon ring, optionally fused to an aryl group, wherein said cycloalkyl ring optionally contains, where possible, up to 2 double bonds;
• and wherein, unless otherwise stated, said cycloalkyl may optionally be substituted with 1 or 2 substituents independently selected from (C1-C6)alkyl, (C1-C6)alkoxy, OH, CN, CF3, COOR14 , halo and NR14R15;
• heterocycloalkyl is a C-linked or N-linked 3 to 10 membered non-aromatic, mono- or bi-cyclic ring, wherein said heterocycloalkyl ring contains, where possible, 1, 2 or 3 heteroatoms independently selected from N, NR14, S(O)q and O;
• and said heterocycloalkyl ring optionally contains, where possible, 1 or 2 double bonds, and is optionally substituted on carbon with 1 or 2 substituents independently selected from (C1-C6)alkyl, (C1-C6)alkoxy, OH, CN, CF3, halo, COOR14, NR14R15 and aryl;
• aryl is a single or fused aromatic ring system containing 6 or 10 carbon atoms;
• wherein, unless otherwise stated, each occurrence of aryl may be optionally substituted with up to 5 substituents independently selected from (C1-C6)alkyl, (C1-C6)alkoxy, OH, halo, CN, COOR14, CF3 and NR14R15;
• heteroaryl is a 5, 6, 9 or 10 membered mono- or bi-cyclic aromatic ring, containing 1 or 2 N atoms and, optionally, an NR14 atom, or one NR14 atom and an S or an O atom, or one S atom, or one O atom;
• wherein, unless otherwise stated, said heteroaryl may be optionally substituted with 1, 2 or 3 substituents independently selected from (C1-C6)alkyl, (C1-C6)alkoxy, OH, halo, CN, COOR14, CF3 and NR14R15;
• q is 0, 1 or 2;
• and tautomers, stereoisomers, pharmaceutically acceptable salts and solvates thereof.