Alpha 1a-adrenoceptor antagonists
AssigneeConcert Pharmaceuticals, Inc.
InventorJulie F. Liu
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Abstract
This invention relates to novel compounds that are dihydroindoles derivatives and pharmaceutically acceptable salts thereof. More specifically, this invention relates to novel dihydroindoles derivatives that are derivatives of silodosin. This invention also provides compositions comprising one or more compounds of this invention and a carrier and the use of the disclosed compounds and compositions in methods of treating diseases and conditions that are beneficially treated by administering an α-1A-adrenoreceptor antagonist, such as silodosin.
Claims20
A compound of Formula I:
- or a pharmaceutically acceptable salt thereof, wherein:
- each R is independently selected from hydrogen or deuterium;
- and
- at least one of R4a, R4b, R5a, R5b, R6a and R6b is deuterium.
A pyrogen-free pharmaceutical composition comprising a compound of Formula I:
- or a pharmaceutically acceptable salt thereof, wherein:
- each R is independently selected from hydrogen or deuterium;
- and
- at least one of R4a, R4b, R5a, R5b, R6a and R6b is deuterium, and a pharmaceutically acceptable carrier.
A method of treating a disease selected from benign prostate hyperplasia (BPH);
- high intraocular pressure;
- high cholesterol;
- impotency;
- female sexual dysfunction (FSD);
- sympathetically mediated pain;
- cardiac arrhythmia;
- migraine;
- and excessive pupil dilation in a subject comprising the step of administering to the subject a compound of Formula I:
- or a pharmaceutically acceptable salt thereof, wherein:
- each R is independently selected from hydrogen or deuterium;
- and
- at least one of R4a, R4b, R5a, R5b, R6a and R6b is deuterium.
Dependencies are inferred from the claim text.