Adjuvant Chemotherapy For Anaplastic Gliomas
AssigneeOklahoma Medical Research Foundation
InventorsRheal A. Towner, Robert A. Floyd
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Abstract
The present invention involves the use of 2,4-disulfonyl phenyl tert-butyl nitrone (2,4-ds-PBN) in the treatment and prevention of gliomas. The 2,4-ds-PBN may be used alone or combined with other traditional chemo- and radiotherapies and surgery, to treat or prevent glioma occurrence, recurrence, spread, growth, metastasis, or vascularization.
Claims29
A method of treating a glioma in a subject comprising administering to said subject a dose of 2,4-disulfonyl phenyl tert-butyl nitrone (2,4-ds-PBN) effective to inhibit the vascularization, growth or spread of said glioma.
A method for inhibiting glioma development in a subject comprising (a) identifying a subject at risk of developing a glioma and (b) administering to said subject a dose of 2,4-disulfonyl phenyl tert-butyl nitrone (2,4-ds-PBN) effective to inhibit the development of said glioma.
A method for inhibiting glioma recurrence comprising administering to a subject previously having a glioma a dose of 2,4-disulfonyl phenyl tert-butyl nitrone (2,4-ds-PBN) effective to inhibit the development of said glioma.
Dependencies are inferred from the claim text.