Topiramate Plus Naltrexone for the Treatment of Addictive Disorders

A method for treating or preventing an addictive disease or disorder in a subject in need thereof, said method comprising administering to said subject an effective amount of at least two compounds, or biologically active analogs, derivatives, modifications, or pharmaceutically acceptable salts thereof, wherein said at least two compounds are selected from the group consisting of serotonergic agents, serotonin antagonists, selective serotonin re-uptake inhibitors, serotonin receptor antagonists, opioid antagonists, dopaminergic agents, dopamine release inhibitors, dopamine antagonists, norepinephrine antagonists, γ-amino-butyric acid agonists, γ-amino-butyric acid inhibitors, γ-amino-butyric acid receptor antagonists, γ-amino-butyric acid channel antagonists, glutamate agonists, glutamate antagonists, glutamine agonists, glutamine antagonists, anti-convulsant agents, N-methyl-D-aspartatc-blocking agents, calcium channel antagonists, carbonic anhydrase inhibitors, neurokinins, small molecules, peptides, vitamins, co-factors, and Corticosteroid Releasing Factor antagonists, thereby treating or preventing an addictive disease or disorder in a subject.