Small molecule inhibitors against west nile virus replication
AssigneeDrexel University
InventorsBaohua Gu, Tim Block, Andy Cuconati
Life of this patent
Estimating the term…
Abstract
The invention provides flavivirus replication inhibitors of WNV and other flaviviruses, such as, for example, JEV, SLEV, AV, KV, JV, CV, YV, TBEV, DENV-1, DENV-2, DENV-3, DENV-4, YFV and MVEV. The invention further provides pharmaceutical compositions including one or more such flavivirus replication inhibitors. The invention further provides methods of treatment, prevention, inhibition or amelioration of one or more diseases associated with flavivirus replication including administering one or more such inhibitors or pharmaceutical compositions.
Claims37
A flavivirus replication inhibitor, wherein the flavivirus replication inhibitor is a compound of Formula (I)
- wherein X, Y and R1-6 are members selected from the group consisting of H, halogen, alkyl, aryl, alkoxy, arylalkyl, cycloalkyl, heterocyclyl, heterocyclylalkyl, heteroaryl, and heteroarylalkyl, wherein each of said alkyl, aryl, alkoxy, arylalkyl, cycloalkyl, heterocyclyl, heterocyclylalkyl, heteroaryl, and heteroarylalkyl can be unsubstituted or optionally substituted with one or more moieties which can be the same or different, each moiety being independently selected from the group consisting of halogen, alkyl, aryl, arylalkyl, cycloalkyl, alkoxy, heterocyclyl, heterocyclylalkyl, heteroaryl, heteroarylalkyl, CF3, OCF3, CN, and —OH.
A flavivirus replication inhibitor, wherein the flavivirus replication inhibitor is a compound of Formula (II)
- wherein R is a member selected from the group consisting of H, alkyl, aryl, alkoxy, arylalkyl, cycloalkyl, heterocyclyl, heterocyclylalkyl, heteroaryl, and heteroarylalkyl, wherein each of said alkyl, aryl, alkoxy, arylalkyl, cycloalkyl, heterocyclyl, heterocyclylalkyl, heteroaryl, and heteroarylalkyl can be unsubstituted or optionally substituted with one or more moieties which can be the same or different, each moiety being independently selected from the group consisting of halogen, alkyl, aryl, arylalkyl, cycloalkyl, alkoxy, heterocyclyl, heterocyclylalkyl, heteroaryl, heteroarylalkyl, CF3, OCF3, CN, and —OH;
- R7 is a member selected from the group consisting of H, halogen, alkyl, aryl, alkoxy, arylalkyl, cycloalkyl, heterocyclyl, heterocyclylalkyl, heteroaryl, and heteroarylalkyl, wherein each of said alkyl, aryl, alkoxy, arylalkyl, cycloalkyl, heterocyclyl, heterocyclylalkyl, heteroaryl, and heteroarylalkyl can be unsubstituted or optionally substituted with one or more moieties which can be the same or different, each moiety being independently selected from the group consisting of halogen, alkyl, aryl, arylalkyl, cycloalkyl, alkoxy, heterocyclyl, heterocyclylalkyl, heteroaryl, heteroarylalkyl, CF3, OCF3, CN, and —OH;
- and
- R8-14 are members selected from the group consisting of H, alkyl, aryl, alkoxy, arylalkyl, cycloalkyl, heterocyclyl, heterocyclylalkyl, heteroaryl, and heteroarylalkyl, wherein each of said alkyl, aryl, alkoxy, arylalkyl, cycloalkyl, heterocyclyl, heterocyclylalkyl, heteroaryl, and heteroarylalkyl can be unsubstituted or optionally substituted with one or more moieties which can be the same or different, each moiety being independently selected from the group consisting of halogen, alkyl, aryl, arylalkyl, cycloalkyl, alkoxy, heterocyclyl, heterocyclylalkyl, heteroaryl, heteroarylalkyl, CF3, OCF3, CN, and —OH.
A flavivirus replication inhibitor, wherein the flavivirus replication inhibitor is a compound of Formula (III)
- wherein R15-27 are members selected from the group consisting of H, halogen, alkyl, aryl, alkoxy, arylalkyl, cycloalkyl, heterocyclyl, heterocyclylalkyl, heteroaryl, and heteroarylalkyl, wherein each of said alkyl, aryl, alkoxy, arylalkyl, cycloalkyl, heterocyclyl, heterocyclylalkyl, heteroaryl, and heteroarylalkyl can be unsubstituted or optionally substituted with one or more moieties which can be the same or different, each moiety being independently selected from the group consisting of halogen, alkyl, aryl, arylalkyl, cycloalkyl, alkoxy, heterocyclyl, heterocyclylalkyl, heteroaryl, heteroarylalkyl, CF3, OCF3, CN, and —OH.
A flavivirus replication inhibitor, wherein the flavivirus replication inhibitor is at least one of
- (a) a compound of Formula (V)
- and derivatives thereof and pharmaceutically acceptable salts, solvates, esters or prodrugs thereof;
- (b) a compound of Formula (VI)
- and derivatives thereof and pharmaceutically acceptable salts, solvates, esters or prodrugs thereof;
- (c) a compound of Formula (VII)
- and derivatives thereof and pharmaceutically acceptable salts, solvates, esters or prodrugs thereof;
- (d) a compound of Formula (VIII)
- and derivatives thereof and pharmaceutically acceptable salts, solvates, esters or prodrugs thereof;
- (e) a compound of Formula (IX)
- and derivatives thereof and pharmaceutically acceptable salts, solvates, esters or prodrugs thereof;
- (f) a compound of Formula (X)
- and derivatives thereof and pharmaceutically acceptable salts, solvates, esters or prodrugs thereof;
- or
- (g) a compound of Formula (XXIII)
- and derivatives thereof and pharmaceutically acceptable salts, solvates, esters or prodrugs thereof.
Dependencies are inferred from the claim text.