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US 2010/0075979 A1Published application
Pyridinylpiperazin derivatives useful as modulators of dopamine d3 receptors
OwnerLuca Gobbi, Georg Jaeschke +2inventors
InventorsLuca Gobbi, Georg Jaeschke, Rosa Maria Rodriguez Sarmiento, Lucinda Steward
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Abstract
The present invention provides compounds of provides formula I, having affinity and selectivity for the dopamine D3 receptors, their manufacture, pharmaceutical compositions containing them and their use for the therapeutic and/or prophylactic treatment of cognitive disorders.
Claims30
A compound of formula I:
- wherein:
- X is independently halogen, C1-6-alkyl, C1-6-haloalkyl or C1-6-alkoxy;
- n is 1 or 2;
- R is C1-6-alkyl, wherein C1-6-alkyl is optionally substituted by —CONH2, C1-6-alkoxy, or one 3 to 6 membered monocyclic cycloalkyl;
- or
- C1-6-alkoxy;
- or a pharmaceutically acceptable salt thereof.
4 more elements
A pharmaceutical composition comprising a therapeutically effective amount of a compound of formula I
- wherein:
- X is independently halogen, C1-6-alkyl, C1-6-haloalkyl or C1-6-alkoxy;
- n is 1 or 2;
- R is C1-6-alkyl, wherein C1-6-alkyl is optionally substituted by —CONH2, C1-6-alkoxy, or one 3 to 6 membered monocyclic cycloalkyl;
- or
- C1-6-alkoxy;
- or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable carrier.
4 more elements
Dependencies are inferred from the claim text.