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AssigneeEgis Gyogyszergyar Nyilvanosan Mukodo Reszvenytarsasag
InventorsIstván Gacsalyi, Gábor Gigler, Márta Agoston, Hajnalka Kompagne, Szabolcs Kertesz, Krisztina Moricz, György Levay, Gábor Szenas, László Gábor Harsing, József Barcoczy, Gyula Simig
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The invention relates the use of 4-chloro-5-{2-[4-(6-fluoro-1,2-benz[d]isoxazole-3-yl)piperidin-1-yl]ethyl-amino}-2-methyl-3-(2H) pyridazinone of the Formula (I) or pharmaceutically acceptable salts thereof for the preparation of medicaments suitable for the improvement of cognitive function or obtaining neuroprotective effect. The medicaments containing 4-chloro-5-{2-[4-(6-fluoro-1,2-benz[d]isoxazol-3-yl)piperidin-1-yl]ethyl-amino}-2-methyl-3-(2H) pyridazinone of the Formula (I) or therapeutically acceptable salt thereof can be used for the treatment or prevention of neuronal death, mental decline, sclerosis multiplex, Creuzfeld-Jacobs disease, Huntington-syndrome, amyotrophic lateral sclerosis, Parkinson-disease, memory disturbance, loss of memory, amnesia, stroke or for the improvement of memory function or learning ability.
1-11. (canceled)
A method for the treatment of neuronal death, mental decline, multiple sclerosis, Creuzfeld-Jacobs disease, Huntington's Disease, amyotrophic lateral sclerosis, Parkinson's Disease or stroke, which comprises the step of administering to a person in need of said treatment a therapeutically effective amount of 4-chloro-5-{2-[4-(6-fluoro-1,2-benz[d]isoxazole-3-yl)piperidin-1-yl]ethyl-amino}-2-methyl-3-(2H)pyridazinone or a pharmaceutically acceptable salt thereof.
A method for the improvement of memory or treatment or prevention of memory loss, memory disturbance or amnesia, which comprises the step of administering to a person in need of said treatment a therapeutically effective amount of 4-chloro-5-{2-[4-(6-fluoro-1,2-benz[d]isoxazole-3-yl)piperidin-1-yl]ethyl-amino}-2-methyl-3-(2H) pyridazinone or a pharmaceutically acceptable salt thereof.
A method for the improvement of learning ability, which comprises the step of administering to a person in need of said treatment a therapeutically effective amount of 4-chloro-5-{2-[4-(6-fluoro-1,2-benz[d]isoxazole-3-yl)piperidin-1-yl]ethyl-amino}-2-methyl-3-(2H)pyridazinone or a pharmaceutically acceptable salt thereof.
A method of preventing hippocampal neuronal damage resulting from global cerebral ischemia in a mammalian subject, which comprises the step of administering to said mammalian subject in need of said treatment a therapeutically effective amount of 4-chloro-5-{2-[4-(6-fluoro-1,2-benz[d]isoxazole-3-yl)piperidin-1-yl]ethyl-amino}-2-methyl-3-(2H)pyridazinone or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.