Angiogenesis

A method for promoting organized vasculature, or for treating, ameliorating or preventing a condition characterized by disorganized vasculature in a subject, the method comprising administering, to a subject in need of such treatment, a therapeutically effective amount of an agent, which selectively modulates β2-adrenergic receptor conformation, or receptor activity, or activation thereof.

A composition comprising therapeutically effective amounts of a β2-adrenergic receptor-selective positive modulator and a β2-adrenergic receptor-selective negative modulator, and optionally a pharmaceutically acceptable vehicle.

A method of promoting organized vasculature in a subject or for treating, preventing, or ameliorating a subject suffering from a condition characterised by disorganized vasculature, the method comprising administering, to a subject in need of said treatment, therapeutically effective amounts of a β2-adrenergic receptor-selective positive modulator and a β2-adrenergic receptor-selective negative modulator.

A delivery system for use in a gene therapy technique, said delivery system comprising a nucleic acid molecule encoding a protein which directly or indirectly selectively modulates β2-adrenergic receptor conformation, or receptor activity, or activation thereof, said nucleic acid molecule being capable of being transcribed to allow expression of said protein, and thereby promote organized vasculature or to treat conditions characterized by disorganized vasculature.

A method for detecting, treating, preventing, or ameliorating cancer in a subject, the method comprising administering, to a subject in need of such treatment, a therapeutically effective amount of an agent, which modulates an endogenous electric potential across a cell.