Imidazolidine Carboxamide Derivatives as P2X7 Modulators

A compound of formula (I):

• wherein:
• R1 represents hydrogen, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-6 cycloalkyl, C3-6 cycloalkylmethyl-, pyridinylmethyl- or benzyl, and wherein any of said C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-6 cycloalkyl, C3-6 cycloalkylmethyl-, pyridinylmethyl- or benzyl is optionally substituted with 1, 2 or 3 halogen atoms;
• or an unsubstituted phenyl;
• R2 represents hydrogen, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-6 cycloalkyl, C3-6 cycloalkylmethyl-, —(CRxRy)n—NR11R12, C6-10 arylmethyl-, heterocyclyl-(CRxRy)n— or heteroaryl-(CRxRy)n—;
• and wherein any of said C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-6 cycloalkyl, C3-6 cycloalkylmethyl-, C6-10 arylmethyl-, heterocyclyl-(CRxRy)n— or heteroaryl-(CRxRy)n— is optionally substituted with 1, 2 or 3 halogen atoms or C1-6 alkyl groups, or the heteroaryl-(CRxRy)n— is optionally substituted on the heteroaryl ring with one C1-3 alkoxy (e.g. methoxy), cyano or trifluoromethyl group;
• R3, R4 and R5 independently represent hydrogen, fluorine or methyl;
• and
• R6, R7, R8, R9 and R10 independently represent hydrogen, halogen, cyano, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-6 cycloalkyl or phenyl, and any of said C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-6 cycloalkyl or phenyl is optionally substituted with 1, 2 or 3 halogen atoms;
• or R9 and R10 together with the carbon atoms to which they are attached form a benzene ring which is optionally substituted with 1, 2 or 3 halogen atoms;
• Rx and Ry independently represent hydrogen or C1-6 alkyl;
• R11 and R12 independently represent hydrogen or C1-6 alkyl;
• n represents an integer from 0 to 4;
• with the proviso that when R6 and R10 independently represent hydrogen or fluorine, at least one of R7, R8 and R9 is a halogen atom, or only one of R7, R8 and R9 is a CF3 group;
• or a pharmaceutically acceptable salt thereof.