Substituted piperazines, (1,4) diazepines, and 2,5-diazabicyclo (2.2.1) heptanes as histamine h1 and/or h3 antagonists or histamine h3 reverse antagonists

A compound of formula (I)

• wherein:
• R1 represents heteroaryl, optionally substituted by one or more:
• halogen;
• trifluoromethyl;
• —C1-6alkyl optionally substituted by COOR15;
• —C1-6alkoxy optionally substituted by COOR15;
• C1-6 alkenyl;
• NR15R16;
• or C1-6alkylthio groups, and in which
• R15 and R16 independently represent hydrogen, C1-6alkyl or C3-8cycloalkyl or together may be fused to form a 5- to 7-membered non-aromatic heterocyclic ring optionally interrupted by an O or S atom and optionally substituted by halogen, C1-6alkyl or —C1-6alkylC1-6alkoxy group;
• wherein R15 and R16 independently represent hydrogen, C1-6alkyl or C3-8cycloalkyl or together may be fused to form a 5- to 7-membered non-aromatic heterocyclic ring optionally interrupted by an O or S atom and optionally substituted by a halogen, C1-6alkyl or C1-6alkylC1-6alkoxy group;
• Z is a bond or CO;
• m is 0 or 2;
• p is 1;
• R3 represents —(CH2)q—NR11R12 in which q represents 3 and
• NR11R12 represents pyrrolidinyl, piperidinyl, azepanyl or azocanyl optionally substituted by one or more C1-6 alkyl groups;
• or a pharmaceutically acceptable salt thereof.