Use of Chemical Chelators as Reversal Agents for Drug-Induced Neuromuscular Block
AssigneeN.V. Organon
InventorsAntonius Helena Adolf Bom, Alan William Muir, David Rees
Life of this patent
Estimating the term…
Abstract
The invention relates to the use of chemical chelators for the preparation of a medicament for the reversal of drug-induced neuromuscular block, to a kit for providing neuromuscular block and its reversal, and to cyclophane derivatives having the general formula A wherein R is (CH2)5, or or the general formula B wherein X is (CH2)5, or or a pharmaceutically acceptable salt thereof.
Claims6
1-11. (canceled)
A method for reversal of drug-induced neuromuscular block in a patient caused by clinically-used neuromuscular blocking agent which acts by reversible binding to the acetylcholine receptor, comprising parenterally administering to said patient an effective amount of a chemical chelator capable of forming a guest-host complex with the neuromuscular blocking agent, wherein the association constant of said guest-host in an aqueous medium at ambient temperature is higher than 10.000 M-1.
Dependencies are inferred from the claim text.