Use of glucocorticoid receptor antagonists for treatment of infectious conditions
AssigneeN.V. Oraganon
InventorBernardus Wijnand Mathys Marie Peeters
Life of this patent
Estimating the term…
Abstract
The invention provides the use of a glucocorticoid receptor antagonist for the manufacture of a medicament for immune stimulation, such as prevention or treatment of infections or infectious conditions, in an aging mammalian subject, a mammalian subject with low serum DHEAS values, a mammalian subject with a high serum cortisol/DHEAS ratio or a mammalian subject with high neutrophil counts. In particular, the glucocorticoid receptor antagonist can be chosen from the group consisting of a dibenzopyranyl derivative defined and/or exemplified in U.S. Pat. No. 6,329,534 and WO200116128, mifepristone, and (11β,17β)-11-(1,3-benzodioxol-5-yl)-17-hydroxy-17-(1-propynyl)estra-4,9-dien-3-one.
Claims11
1-10. (canceled)
A method for providing immune stimulation in a mammalian subject in need thereof, wherein the mammalian subject is selected from the group consisting of an aging mammalian subject, a subject with low serum DHEAS values, a subject with a high serum cortisol/DHEAS ratio and a subject with high neutrophil counts, the method comprising administering a therapeutically effective amount of a glucocorticoid receptor antagonist to the mammalian subject.
Dependencies are inferred from the claim text.