9-aminoacyl tetracycline compounds and methods of use thereof

A method for the treatment of a bacterial infection in a subject, which comprises administering to the subject an effective amount of a compound of formula (I):

• wherein:
• R represents hydrogen or NRaRb;
• R1 represents hydrogen or C1-6alkyl;
• R2 represents hydrogen or hydroxy;
• R3 represents hydrogen;
• R4 represents hydrogen;
• R5 represents hydrogen, C1-6alkyl or C1-6alkoxycarbonyl;
• X represents NRxRy or —OC1-6alkyl optionally substituted by one or more groups selected from hydroxyl, methoxy, halogen, amino and trifluoromethyl;
• Ra and Rb independently represent hydrogen or C1-6alkyl;
• and
• Rx and Ry independently represent hydrogen, benzyl, C3-6cycloalkyl, C3-6alkenyl, C3-6alkynyl, C1-6alkyl optionally substituted by one or more groups selected from hydroxy, methoxy, halogen, NRaRb and trifluoromethyl, —C1-6alkylcycloalkyl, —C1-6alkylheterocycle, C1-6alkylamino and C1-6alkylthio or together Rx and Ry form a heterocycle;
• or a pharmaceutically acceptable salt thereof.