Activation of histone deacetylase 1 (hdac1) protects against dna damage and increases neuronal survival

A compound of the formula:

• wherein
• n is an integer between 1 and 6, inclusive;
• m is an integer between 1 and 6, inclusive;
• p is an integer between 1 and 6, inclusive;
• q is an integer between 1 and 6, inclusive;
• t is an integer between 1 and 6, inclusive;
• R0 is hydrogen, hydroxyl, acyl, or a nitrogen protecting group;
• R1 is hydrogen, hydroxyl, acyl, or a nitrogen protecting group;
• R2 is hydrogen, hydroxyl, acyl, or a nitrogen protecting group;
• R3 is hydrogen, hydroxyl, acyl, or a nitrogen protecting group;
• R4 is hydrogen, hydroxyl, acyl, or a nitrogen protecting group;
• R5 is hydrogen, hydroxyl, acyl, or a nitrogen protecting group;
• R6 is hydrogen, hydroxyl, acyl, or a nitrogen protecting group;
• R7 is hydrogen, hydroxyl, acyl, or a nitrogen protecting group;
• and a pharmaceutically acceptable salt thereof

A compound of the formula:

• wherein
• n is an integer between 1 and 4, inclusive;
• each of R1 is independently hydrogen;
• halogen;
• cyclic or acyclic, substituted or unsubstituted, branched or unbranched aliphatic;
• cyclic or acyclic, substituted or unsubstituted, branched or unbranched heteroaliphatic;
• substituted or unsubstituted, branched or unbranched acyl;
• substituted or unsubstituted, branched or unbranched aryl;
• substituted or unsubstituted, branched or unbranched heteroaryl;
• —ORA;
• —C(═O)RA;
• —CO2RA;
• —CN;
• —SCN;
• —SRA;
• —SORA;
• —SO2RA;
• —NO2;
• —N3;
• —N(RA)2;
• —NHC(═O)RA;
• —NRAC(═O)N(RA)2;
• —OC(═O)ORA;
• —OC(═O)RA;
• —OC(═O)N(RA)2;
• —NRAC(═O)ORA;
• or —C(RA)3;
• wherein each occurrence of RA is independently a hydrogen, a protecting group, an aliphatic moiety, a heteroaliphatic moiety, an acyl moiety;
• an aryl moiety;
• a heteroaryl moiety;
• alkoxy;
• aryloxy;
• alkylthio;
• arylthio;
• amino, alkylamino, dialkylamino, heteroaryloxy;
• or heteroarylthio moiety;
• and pharmaceutically acceptable salts thereof.

A compound of the formula:

• wherein
• R1 is hydrogen;
• halogen;
• cyclic or acyclic, substituted or unsubstituted, branched or unbranched aliphatic;
• cyclic or acyclic, substituted or unsubstituted, branched or unbranched heteroaliphatic;
• substituted or unsubstituted, branched or unbranched acyl;
• substituted or unsubstituted, branched or unbranched aryl;
• substituted or unsubstituted, branched or unbranched heteroaryl;
• —ORA;
• —C(═O)RA;
• —CO2RA;
• —CN;
• —SCN;
• —SRA;
• —SORA;
• —SO2RA;
• —NO2;
• —N3;
• —N(RA)2;
• —NHC(═O)RA;
• —NRAC(═O)N(RA)2;
• —OC(═O)ORA;
• —OC(═O)RA;
• —OC(═O)N(RA)2;
• —NRAC(═O)ORA;
• or —C(RA)3;
• wherein each occurrence of RA is independently a hydrogen, a protecting group, an aliphatic moiety, a heteroaliphatic moiety, an acyl moiety;
• an aryl moiety;
• a heteroaryl moiety;
• alkoxy;
• aryloxy;
• alkylthio;
• arylthio;
• amino, alkylamino, dialkylamino, heteroaryloxy;
• or heteroarylthio moiety;
• R2 is cyclic or acyclic, substituted or unsubstituted, branched or unbranched aliphatic;
• cyclic or acyclic, substituted or unsubstituted, branched or unbranched heteroaliphatic;
• substituted or unsubstituted, branched or unbranched acyl;
• substituted or unsubstituted, branched or unbranched aryl;
• substituted or unsubstituted, branched or unbranched heteroaryl;
• —ORB;
• —OH;
• or —C(RB)3;
• wherein each occurrence of RB is independently a hydrogen, a protecting group, an aliphatic moiety, a heteroaliphatic moiety, an acyl moiety;
• an aryl moiety;
• a heteroaryl moiety;
• alkoxy;
• aryloxy;
• alkylthio;
• arylthio;
• amino, alkylamino, dialkylamino, heteroaryloxy;
• or heteroarylthio moiety;
• and pharmaceutically acceptable salts thereof.

A compound of the formula:

• wherein
• each is independently a single or double bond;
• each of R1 and R2 is independently hydrogen;
• cyclic or acyclic, branched or unbranched, substituted or unsubstituted aliphatic;
• cyclic or acyclic, substituted or unsubstituted, branched or unbranched heteroaliphatic;
• substituted or unsubstituted, branched or unbranched acyl;
• substituted or unsubstituted aryl, substituted or unsubstituted, branched or unbranched heteroaryl;
• —ORA;
• —C(═O)RA;
• —CO2RA;
• —CN;
• —SCN;
• —SRA;
• —SORA;
• —SO2RA;
• —NO2;
• —N3;
• —N(RA)2;
• —NHC(═O)RA;
• —NRAC(═O)N(RA)2;
• —OC(═O)ORA;
• —OC(═O)RA;
• —OC(═O)N(RA)2;
• —NRAC(═O)ORA;
• or —C(RA)3;
• wherein each occurrence of RA is independently a hydrogen, a protecting group, an aliphatic moiety, a heteroaliphatic moiety, an acyl moiety;
• an aryl moiety;
• a heteroaryl moiety;
• alkoxy;
• aryloxy;
• alkylthio;
• arylthio;
• amino, alkylamino, dialkylamino, heteroaryloxy;
• or heteroarylthio moiety;
• each of R3, and R4 is independently —OH, alkoxy, —Oacyl, ═O, or wherein R3 and R4 are taken together to form a cyclic structure;
• each of R5 is independently hydrogen;
• cyclic or acyclic, branched or unbranched, substituted or unsubstituted aliphatic;
• and pharmaceutically acceptable salts thereof.

A compound of the formula:

• wherein
• n is an integer between 0 and 4, inclusive;
• m is an integer between 0 and 5, inclusive;
• each of R1 and R2 is independently —OH;
• alkoxy;
• —Oacyl;
• —OAc;
• —OPG;
• substituted or unsubstituted aryl;
• wherein either R1 or R2 can be a second HDAC1 activator moiety;
• and pharmaceutically acceptable salts thereof.

A compound of the formula:

• wherein
• n is an integer between 0 and 4, inclusive;
• m is an integer between 0 and 4, inclusive;
• each of R1 and R2 is independently —OH;
• alkoxy;
• —Oacyl;
• —OAc;
• —OPG;
• substituted or unsubstituted aryl;
• and pharmaceutically acceptable salts thereof.

A compound of the formula:

• wherein
• is independently a single or double bond;
• R1 is hydrogen;
• cyclic or acyclic, substituted or unsubstituted, branched or unbranched aliphatic;
• cyclic or acyclic, substituted or unsubstituted, branched or unbranched heteroaliphatic;
• substituted or unsubstituted, branched or unbranched aryl;
• substituted or unsubstituted, branched or unbranched heteroaryl;
• R2 is hydrogen;
• cyclic or acyclic, substituted or unsubstituted, branched or unbranched aliphatic;
• cyclic or acyclic, substituted or unsubstituted, branched or unbranched heteroaliphatic;
• substituted or unsubstituted, branched or unbranched acyl;
• substituted or unsubstituted, branched or unbranched aryl;
• substituted or unsubstituted, branched or unbranched heteroaryl;
• —C(═O)RB;
• —CO2RB;
• or —C(RB)3;
• wherein each occurrence of RB is independently a hydrogen, a protecting group, an aliphatic moiety, a heteroaliphatic moiety, an acyl moiety;
• an aryl moiety;
• a heteroaryl moiety;
• alkoxy;
• aryloxy;
• alkylthio;
• arylthio;
• amino, alkylamino, dialkylamino, heteroaryloxy;
• or heteroarylthio moiety;
• X is ═O,
• and pharmaceutically acceptable salts thereof.