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AssigneesMaria I. C. Gyongyossy-Issa, Dana V. Devine, Iren Constantinescu, William Campbell, Carlos A. Del Carpio Mundoz
InventorsMaria I. C. Gyongyossy-Issa, Dana V. Devine, Iren Constantinescu, William Campbell, Carlos A. Del Carpio Munoz
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It is provided mimotope receptors and inhibitors that employ peptide mimics that mimic the shape and function of natural receptors and ligands, thus providing synthetic binding sites for ligands and receptors. Receptor mimics can be attached to carriers, such as liposomes, to act as synthetic platelets, for example, by providing multiple binding sites for binding to other (natural or synthetic) platelets or to the endothelium. Synthetic platelets would have virtually limitless shelf life and would not require disease screening prior to transfusion, thereby providing a solution to the perpetual platelet shortages, as well as the safety and storage issues associated with natural blood platelets.
A peptide mimotope capable of inhibiting an interaction between a platelet receptor and a platelet receptor ligand.
A method of identifying a receptor mimotope of a platelet receptor that can inhibit the interaction between the platelet receptor and a platelet receptor ligand, said method comprising the steps of:
A method of identifying a ligand mimotope of a platelet receptor ligand that can inhibit the interaction between a platelet receptor and the platelet receptor ligand, said method comprising the steps of:
Dependencies are inferred from the claim text.