Back to results
US 2010/0075906 A1Published application
Targeted Therapeutic Proteins
AssigneeZyStor Therapeutics, Inc.
InventorsJonathan H. LeBowitz, Stephen M. Beverley, William S. Sly
Life of this patent
Estimating the term…
Abstract
Targeted therapeutics that localize to a specific subcellular compartment such as the lysosome are provided. The targeted therapeutics include a therapeutic agent and a targeting moiety that binds a receptor on an exterior surface of the cell, permitting proper subcellular localization of the targeted therapeutic upon internalization of the receptor. Nucleic acids, cells, and methods relating to the practice of the invention are also provided.
Claims2
An underglycosylated targeted therapeutic comprising:
- a therapeutic agent that is therapeutically active in a human lysosome;
- and
- a lysosomal targeting domain that binds an extracellular domain of human cation-independent mannose-6-phosphate receptor and
- (i) does not bind a mutein in which amino acid 1572 of the human cation-independent mannose-6-phosphate receptor is changed from isoleucine to threonine;
- or
- (ii) binds the mutein with a dissociation constant at least ten times the dissociation constant for binding the extracellular domain of human cation-independent mannose-6-phosphate receptor.
3 more elements
2-37. (canceled)
Dependencies are inferred from the claim text.