Novel use of hiv nc protein
AssigneesJi Chang You, Avixgen Inc.
InventorJi Chang You
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Abstract
The present invention relates to a novel use of the HIV NC protein, and more particularly, it is relates to a pharmaceutical composition for preventing and treating AIDS having a polypeptide comprising HIV NC protein as an active component and the method of inhibiting HIV proliferation by using the polypeptide. The polypeptide comprising HIV NC protein of the present invention, when it is overexpressed, has the effect on inhibiting HIV proliferation. Accordingly, the present invention provides not only the novel means of inhibition of HIV proliferation, but also the novel method for preventing and treating AIDS.
Claims18
A pharmaceutical composition for preventing and treating AIDS (acquired immune deficiency syndrome) having a polypeptide comprising HIV NC (human immunodeficiency virus nucleocapsid) protein as an active component.
A pharmaceutical composition for preventing and treating AIDS (acquired immune deficiency syndrome) comprising an expression vector which comprise a promoter and a polynucleotide encoding a polypeptide comprising an HIV NC (human immunodeficiency virus nucleocapsid) protein operably linked to the promoter as an effective component.
A method for inhibiting HIV proliferation by increasing the intracellular level of a polypeptide comprising HIV NC protein.
A screening method of agents for preventing or treating AIDS comprising the steps of:
- (a) culturing recombinant cells expressing the polypeptide comprising HIV NC protein with a candidate substance;
- and
- (b) measuring the effect of the candidate substance on increasing the intracellular level of the polypeptide comprising HIV NC protein.
Use of the HIV NC (human immunodeficiency virus nucleocapsid) protein for manufacturing agents for treating AIDS (acquired immune deficiency syndrome).
A method for preventing or treating AIDS (acquired immune deficiency syndrome) comprising administering to subject in need thereof an effective amount of HIV NC (human immunodeficiency virus nucleocapsid) protein.
Dependencies are inferred from the claim text.