Repair of larynx, trachea, and other fibrocartilaginous tissues
AssigneeStryker Corporation
InventorsSlobodan Vukicevic, Vladimir Katic, Kuber T. Sampath
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Abstract
Provided herein are methods and devices for inducing the formation of functional replacement nonarticular cartilage tissues and ligament tissues. These methods and devices involve the use of osteogenic proteins, and are useful in repairing defects in the larynx, trachea, interarticular menisci intervertebral discs, ear, nose, ribs and other fibrocartilaginous tissues in a mammal.
Claims20
1-56. (canceled)
A method for repairing a nonarticular cartilage defect comprising the step of administering to the cartilage defect an effective amount of a composition comprising an osteogenic protein selected from the group consisting of OP-1, OP-2, OP-3, BMP-2, BMP-3, BMP-4, BMP-5, BMP-6, BMP-9, BMP-10, BMP-11, BMP-15, BMP-3B, DPP, Vg-1, Vgr-1, 60A protein, GDF-1, GDF-2, GDF-3, GDF-5, GDF-6, GDF-7, GDF-8, GDF-9, GDF-10 and GDF-11;
- and a carrier selected from the group consisting of a liquid, semi-liquid and gel carrier.
A method for repairing an interarticular meniscus defect comprising the step of administering to the meniscus defect an effective amount of a composition comprising an osteogenic protein selected from the group consisting of OP-1, OP-2, OP-3, BMP-2, BMP-3, BMP-4, BMP-5, BMP-6, BMP-9, BMP-10, BMP-l 11, BMP-15, BMP-3B, DPP, Vg-1, Vgr-1, 60A protein, GDF-1, GDF-2, GDF-3, GDF-5, GDF-6, GDF-7, GDF-8, GDF-9, GDF-10 and GDF-11;
- and a carrier selected from the group consisting of a liquid, semi-liquid and gel carrier.
A device for inducing nonarticular cartilage formation, the device comprising an osteogenic protein selected from the group consisting of OP-1, OP-2, OP-3, BMP-2, BMP-3, BMP-4, BMP-5, BMP-6, BMP-9, BMP-10, BMP-11, BMP-15, BMP-3B, DPP, Vg-1, Vgr-1, 60A protein, GDF-1, GDF-2, GDF-3, GDF-5, GDF-6, GDF-7, GDF-8, GDF-9, GDF-10 and GDF-11;
- and a carrier selected from the group consisting of a liquid, semi-liquid and gel carrier.
Dependencies are inferred from the claim text.