Preparation of a pharmaceutical composition for increasing bone mineral density
AssigneeN.V. Organon
InventorsJan Albert Gossen, Johannes Petrus Leonardus Gerrits
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Abstract
The present invention relates to the use of a cocaine and amphetamine-regulated transcript (CART)-derived peptide for the preparation of a pharmaceutical composition for increasing bone mineral density by continuously providing elevated serum levels of the CART-derived peptide in a subject to be treated. Suitably, the elevated serum levels of the CART-derived peptide are continuously provided through slow release of the CART-derived peptide over an extended period of time from a slow release formulation.
Claims23
A pharmaceutical composition for increasing bone mineral density comprising a cocaine and amphetamine-regulated transcript (CART)-derived peptide that has the biological activity of human CART and a suitable excipient in a slow release formulation.
A method for increasing bone mineral density in a subject in need thereof, comprising continuously providing elevated serum levels of a cocaine and amphetamine-regulated transcript (CART)-derived peptide that has the biological activity of human CART to the subject.
Dependencies are inferred from the claim text.