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US 2010/0075414 A1Published application
Growth of foreign cells after conditional and selective destruction of fetal host cells
AssigneeXimerex, Inc.
InventorsWilliam E. Beschorner, Carlos E. Sosa, Scott C. Thompson
Life of this patent
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Abstract
Foreign cells can be grown in fetal non-mammalian hosts for the production of transplant organs and tissues, the development of new therapeutic agents, and the production of biological factors and drugs. Tissue-specific injury to fetal host target cells is carried without substantial injury to the maternal host or foreign cells, providing an environment in which the injured tissue can be regenerated with the foreign cells.
Claims23
A method of obtaining an expanded population of foreign replacement cells, comprising steps of:
- (a) selectively destroying native cells in a tissue of a fetal non-human mammal host, wherein the number of maternal cells of the same tissue is not substantially reduced;
- (b) implanting foreign replacement cells in the tissue of the fetal non-human mammal host, whereby the foreign replacement cells replace destroyed native tissue cells, thereby forming a chimeric tissue comprising an expanded population of foreign replacement cells;
- and
- (c) separating the expanded population of foreign replacement cells from the chimeric tissue.
1 more element
Dependencies are inferred from the claim text.