Novel peptides

An energy-modulating agent comprising as an active ingredient at least one peptide selected from (a) to (f) below or a pharmaceutically acceptable salt thereof:

• (a) a peptide comprising the amino acid sequence of any one of SEQ ID NOS:
• 1 to 12, and 23 to 29;
• (b) a peptide comprising an amino acid sequence with substitution, deletion, or addition of one to five amino acids in the amino acid sequence of any one of SEQ ID NOS:
• 1 to 12, and 23 to 29, wherein the peptide has an activity of increasing the intracellular calcium ion concentration in a cell of hypothalamus, pituitary gland, or brain tissue;
• (c) a peptide comprising an amino acid sequence having 90% or higher homology to the amino acid sequence of any one of SEQ ID NOS:
• 1 to 12, and 23 to 29, wherein the peptide has an activity of increasing the intracellular calcium ion concentration in a cell of hypothalamus, pituitary gland, or brain tissue;
• (d) a peptide comprising an amino acid sequence with substitution, deletion, or addition of one to five amino acids in the amino acid sequence of any one of SEQ ID NOS:
• 1, 25, 28, and 29, wherein the peptide has an activity of promoting vasopressin secretion from the posterior pituitary gland;
• (e) a peptide comprising an amino acid sequence having 90% or higher homology to the amino acid sequence of any one of SEQ ID NOS:
• 1, 25, 28, and 29, wherein the peptide has an activity of promoting vasopressin secretion from the posterior pituitary gland;
• and
• (f) a peptide represented by the following formula (II)
• R3—B—R4 (II)
• (wherein, R3 represents a hydrogen atom, substituted or unsubstituted alkanoyl, substituted or unsubstituted aroyl, substituted or unsubstituted heteroarylcarbonyl, substituted or unsubstituted alkoxycarbonyl, substituted or unsubstituted aryloxycarbonyl, or substituted or unsubstituted heteroaryloxycarbonyl;
• R4 represents hydroxy, substituted or unsubstituted alkoxy, or substituted or unsubstituted amino;
• and B represents a peptide residue of the peptide of any one of the above-mentioned (a) to (e)).

A circulation-modulating agent comprising as an active ingredient at least one peptide selected from (a) to (f) below or a pharmaceutically acceptable salt thereof:

• (a) a peptide comprising the amino acid sequence of any one of SEQ ID NOS:
• 1 to 12;
• (b) a peptide comprising an amino acid sequence with substitution, deletion, or addition of one to five amino acids in the amino acid sequence of any one of SEQ ID NOS:
• 1 to 12, wherein the peptide has an activity of increasing the intracellular calcium ion concentration in a cell of kidney, heart, or blood vessel;
• (c) a peptide comprising an amino acid sequence having 90% or higher homology to the amino acid sequence of any one of SEQ ID NOS:
• 1 to 12, wherein the peptide has an activity of increasing the intracellular calcium ion concentration in a cell of kidney, heart, or blood vessel;
• (d) a peptide comprising an amino acid sequence with substitution, deletion, or addition of one to five amino acids in the amino acid sequence of any one of SEQ ID NOS:
• 1, 25, 28, and 29, wherein the peptide has an activity of promoting vasopressin secretion from the posterior pituitary gland;
• (e) a peptide comprising an amino acid sequence having 90% or higher homology to the amino acid sequence of any one of SEQ ID NOS:
• 1, 25, 28, and 29, wherein the peptide has an activity of promoting vasopressin secretion from the posterior pituitary gland;
• and
• (f) a peptide represented by the following formula (III)
• R5—C—R6 (III)
• (wherein, R5 represents a hydrogen atom, substituted or unsubstituted alkanoyl, substituted or unsubstituted aroyl, substituted or unsubstituted heteroarylcarbonyl, substituted or unsubstituted alkoxycarbonyl, substituted or unsubstituted aryloxycarbonyl, or substituted or unsubstituted heteroaryloxycarbonyl;
• R6 represents hydroxy, substituted or unsubstituted alkoxy, or substituted or unsubstituted amino;
• and C represents a peptide residue of the peptide of any one of the above-mentioned (a) to (e)).