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US 2010/0075342 A1Published application
Biomarker for ovarian cancer CTAP3-related proteins
AssigneesThe Johns Hopkins University, Vermillion, Inc.
InventorsZhen Zhang, Daniel W. Chan, Eric T. Fung, Zheng Wang, Fujun Zhang
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Abstract
The present invention provides a protein-based biomarker that is useful in qualifying ovarian cancer status in a patient. In particular, the biomarker of this invention is useful to classify a subject sample as ovarian cancer or non-ovarian cancer. The biomarker can be detected by SELDI mass spectrometry.
Claims22
A method for qualifying ovarian cancer status in a subject comprising:
- (a) measuring at least one biomarker including a CTAP3-related protein in a biological sample from the subject;
- and
- (b) correlating the measurement with ovarian cancer status.
(canceled)
A method for determining the course of ovarian cancer comprising:
- (a) measuring, at a first time, at least one biomarker including a CTAP3-related protein in a biological sample from the subject;
- (b) measuring, at a second time, the CTAP3-related protein in a biological sample from the subject;
- and
- (c) comparing the first measurement and the second measurement;
- wherein the comparative measurements determine the course of the ovarian cancer.
2 more elements
A kit comprising:
- (a) a solid support comprising at least one capture reagent attached thereto, wherein the capture reagent binds to a CTAP3-related protein;
- and
- (b) instructions for using the solid support to detect the CTAP3-related protein.
-35. (canceled)
Dependencies are inferred from the claim text.