Methylation biomarker for early detection of gastric cancer
OwnerYong Sung Kim, Seung Moo Noh +8inventors
InventorsYong Sung Kim, Seung Moo Noh, Hyang Sook Yoo, Jeong Hwan Kim, Mi Rang Kim, Hay Ran Jang, Kyu Sang Song, June Sik Cho, Seon-Young Kim, Hyun Yong Jeong
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Abstract
The present application describes a method of diagnosing gastric cancer or a stage in the progression of the cancer in a subject comprising assaying for loss of expression of a marker gene such as POPDC3, CCDC67, LRRC3B, PRKD1, CYP1B1, LIMS2, DCBLD2, LOC149351, ADCY8, BACH2, ALOX5, TCF4, CXXC4, CAMK2N2, EMX1, KCNK9, NCAM2, AMPD3, NOG, SP6, LOC100128675, or CHSY3, or a combination thereof.
Claims20
A method of diagnosing gastric cancer or a stage in the progression of the cancer in a subject comprising assaying for loss of expression of a marker gene, which is selected from the group consisting of:
- POPDC3, CCDC67, LRRC3B, PRKD1, CYP1B1, LIMS2, DCBLD2, LOC149351, ADCY8, BACH2, ALOX5, TCF4, CXXC4, CAMK2N2, EMX1, KCNK9, NCAM2, AMPD3, NOG, SP6, LOC100128675, and CHSY3, or a combination thereof.
A method of diagnosing likelihood of developing gastric cancer comprising assaying for methylation of a gastric cancer specific marker gene in normal appearing bodily sample.
A kit comprising
- (i) a carrier means compartmentalized to receive a sample therein, and
- (ii) one or more containers comprising a first container containing a reagent which sensitively cleaves unmethylated cytosine, a second container containing primers for amplification of a CpG-containing nucleic acid, and a third container containing a means to detect the presence of cleaved or uncleaved nucleic acid.
Dependencies are inferred from the claim text.