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US 2010/0075314 A1Published application
Chemically-modified gold nanoparticles and methods for use in detecting target molecules
OwnerViswanadham Garimella, Thomas F. Holzman +1inventors
InventorsViswanadham Garimella, Thomas F. Holzman, Yijia P. Bao
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Abstract
The invention provides stable bioconjugate-nanoparticle probes which are useful for detecting nucleic acids and other target analytes, e.g., proteins, and methods of preparing those probes.
Claims21
A compound of formula (I):
- L-PO2—O((-T-O—PO2—O)m—Zn)q-biotin, wherein L represents a steroid with a cyclic disulfide functional group;
- wherein T represents thymidine;
- wherein each Z independently represents a polyglycol which may be the same or different;
- wherein n ranges from 3 to 20;
- wherein q ranges from 1 to 20;
- wherein m is 0 or 1;
- and wherein each polyglycol independently comprises from 1 to 60 carbon atoms and includes from 1 to 30 non-peroxide —O—.
4 more elements
Dependencies are inferred from the claim text.