Polymorphisms in genes affecting cns disorders and uses thereof
AssigneeThe Ohio State University Research Foundation
InventorsWolfgang Sadee, David Saffen, Julia Pinsonneault, Audrey Papp, Ying Zhang, Jeong-Eun Lim, Danxin Wang
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Estimating the term…
Abstract
Diagnostic and prognostic methods, compositions, assays, and kits useful for predicting the phenotype of subjects who have, or are at risk of developing, a mental disorder. The methods also include predicting the prognostic outcome of a subject's mental disorder as well as the subject's responsiveness to drug treatments for the mental disorder. The methods and kits include determining the allelic status of polymorphisms in the MAOA, TPH2 and DRD2 genes.
Claims47
A method for predicting a subject's risk for having or developing a mental disorder comprising detecting the allelic status of one or more polymorphisms in a nucleic acid sample of the subject, wherein the polymorphism is selected from the group consisting of:
- i. tryptophan hydroxylase 2 (TPH2)-associated SNP's rs7305115, rs2171363, rs4760815, rs6582078, rs9325202, and combinations thereof;
- and
- ii. a SNP in linkage disequilibrium with one or more SNPs listed in i;
- wherein the allelic status of the polymorphism in the subject is predictive of the subject's risk for having or developing a mental disorder.
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A method of screening a subject for a prognostic biomarker of a mental disorder, comprising detecting the allelic status of one or more polymorphisms in a nucleic acid sample of the subject, wherein the polymorphism is selected from the group consisting of
- i. tryptophan hydroxylase 2 (TPH2)-associated SNP's rs2171363, rs4760815, rs7305115, rs6582078, rs9325202, and combinations thereof;
- and
- ii. a SNP in linkage disequilibrium with one or more SNPs listed in i;
- wherein the allelic status of the polymorphism in the subject is predictive of the prognostic outcome of the mental disorder.
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A kit comprising an assay for detecting the allelic status of one or more polymorphisms in a nucleic acid sample of a subject, wherein the polymorphism is selected from the group consisting of:
- i. tryptophan hydroxylase 2 (TPH2)-associated SNP's rs2171363, rs4760815, rs7305115, rs6582078, rs9325202, and combinations thereof;
- and
- ii. a SNP in linkage disequilibrium with one or more SNP's listed in i.
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Dependencies are inferred from the claim text.