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US 2010/0075304 A1Published application
Process for monitoring colorectal cancer
OwnerMitch Raponi, Gregory M. Arndtinventors
Life of this patent
Estimating the term…
Abstract
Disclosed in this specification is a method for determining the stage of colorectal cancer by observing regulatory changes in select miRNA sequences. These sequences may include hsa-miR-31, hsa-miR-7, hsa-miR-99b, hsa-miR-378*, hsa-miR-133a, hsa-miR-125a and combinations of these sequences.
Claims17
A process for determining the stage of colorectal cancer in humans comprising the steps of:
- observing a regulation change of a microRNA from extracted RNA relative to the same microRNA in a wild type colorectal tissue sample, wherein the microRNA is selected from the group consisting of SEQ ID NO. 38, SEQ ID NO. 39, SEQ ID NO. 25, SEQ ID NO. 33, SEQ ID NO. 31, and combinations thereof;
- determining the stage of colorectal cancer based on the observed regulation change.
A process for diagnosing the stage of colorectal cancer in humans comprising the steps of:
- extracting RNA from a colorectal cell;
- observing a regulation change of at least two microRNAs from the extracted RNA relative to the same microRNAs in a normal colorectal tissue sample, wherein the microRNAs are selected from the group consisting of SEQ ID NO. 20, SEQ ID NO. 38, SEQ ID NO. 39, SEQ ID NO. 25, SEQ ID NO. 33, SEQ ID NO. 31, and combinations thereof;
- determining the stage of colorectal cancer based on the observed regulation change.
A process for diagnosing the stage of colorectal cancer in humans comprising the steps of:
- observing a regulation change of at least two microRNAs that include both SEQ ID NO. 20 and SEQ ID NO. 38;
- determining the stage of colorectal cancer based on the observed regulation change.
Dependencies are inferred from the claim text.