Amino nicotinic and isonicotinic acid derivatives as dhodh inhibitors

A compound of formula (I)

• wherein
• one of the groups G1 groups is chosen from a nitrogen atom and a CRC group and the other G1 group represents a CRC group;
• G2 is chosen from a nitrogen atom and a CRd group;
• R1 is chosen from hydrogen atoms, halogen atoms, C1-4 alkyl groups, which may be optionally substituted by 1, 2 or 3 substituents chosen from halogen atoms and hydroxy groups, and C3-8 cycloalkyl groups which may be optionally substituted by 1, 2 or 3 substituents chosen from halogen atoms and hydroxy groups;
• R2 is chosen from hydrogen atoms, halogen atoms, hydroxyl groups, C1-4 alkyl groups, which may be optionally substituted by 1, 2 or 3 substituents chosen from halogen atoms and hydroxy groups, C1-4 alkoxy groups, which may be optionally substituted by 1, 2 or 3 substituents chosen from halogen atoms and hydroxy groups, and C3-8 cycloalkyl groups, which may be optionally substituted by 1, 2 or 3 substituents selected chosen from halogen atoms and hydroxy groups;
• Ra, Rb and Rc are each independently chosen from hydrogen atoms, halogen atoms, C1-4 alkyl groups, which may be optionally substituted by 1, 2 or 3 substituents chosen from halogen atoms and hydroxy groups, and C1-4 alkoxy groups, which may be optionally substituted by 1, 2 or 3 substituents chosen from halogen atoms and hydroxy groups;
• Rd is chosen from hydrogen atoms, halogen atoms, hydroxyl groups, C1-4 alkyl groups, which may be optionally substituted by 1, 2 or 3 substituents chosen from halogen atoms, and hydroxy groups, C1-4 alkoxy groups, which may be optionally substituted by 1, 2 or 3 substituents chosen from halogen atoms and hydroxy groups, and C3-8 cycloalkoxy groups, which may be optionally substituted by 1, 2 or 3 substituents chosen from halogen atoms and hydroxy groups;
• one of the groups G3 and G4 is a nitrogen atom and the other is a CH group;
• and
• M is a hydrogen atom or an pharmaceutically acceptable cation;
• with the proviso that, when at least one of the groups Ra and Rb represent a hydrogen atom and G2 is a CRd group, then Rd is chosen from C1-4 alkoxy groups, which may be optionally substituted by 1, 2 or 3 substituents chosen from halogen atoms and hydroxy groups, and C3-8 cycloalkoxy groups, which may be optionally substituted by 1, 2 or 3 substituents chosen from halogen atoms and hydroxy groups;
• or a pharmaceutically acceptable salt or N-oxide thereof.