Methods for Treating and Diagnosing Fibrotic and Fibroproliferative Diseases
AssigneeUniversity of Virginia Patent Foundation
InventorsBorna Mehrad, Marie D. Burdick, David A. Zisman, Michael P. Keane, John A. Belperio, Robert M. Strieter
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Abstract
The present invention provides compositions and methods for diagnosing and treating fibrotic lung disease.
Claims41
A method of diagnosing a subject with a fibrotic disease or disorder comprising determining the number of circulating fibrocytes in said subject, wherein an increase in the number of circulating fibrocytes in said subject compared to the number of circulating fibrocytes in a control subject is indicative of a fibrotic disease or disorder.
A method of diagnosing a subject with a fibrotic disease or disorder comprising determining the amount of circulating CXCL-12 in said subject, wherein an increase in the amount of circulating CXCL-12 in said subject compared to the amount of circulating CXCL-12 in a control subject is indicative of a fibrotic disease or disorder.
A method of determining the progression of a fibroproliferative disease in a subject suffering from a fibroproliferative disorder comprising determining the number of circulating fibrocytes in said subject, wherein an increase over time in the number of circulating fibrocytes in said subject is indicative of a progression of said fibroproliferative disease or disorder.
A method of treating a subject suffering from a fibrotic or fibroproliferative disease or disorder comprising administering a compound or biologic that reduces the number of circulating fibrocytes.
A medicament for the treatment of a fibrotic or fibroproliferative disease or disorder comprising a compound or biologic that reduces the number of circulating fibrocytes.
Dependencies are inferred from the claim text.