Methods and kits for predicting prognosis of multiple sclerosis
AssigneeTel Hashomer Medical Research Infrastructure and S
InventorsAnat Achiron, Michael Gurevich
Life of this patent
Estimating the term…
Abstract
Provided are methods and kits for predicting the prognosis of a subject diagnosed with multiple sclerosis by determining the expression level of polynucleotides which are differentially expressed between subjects diagnosed with multiple sclerosis and having good or poor clinical outcome. Also provided are methods and kits for selecting a treatment regimen of a subject diagnosed with multiple sclerosis.
Claims24
A method of predicting a prognosis of a subject diagnosed with multiple sclerosis, the method comprising determining in a cell of the subject a level of expression of at least one polynucleotide sequence selected from the group consisting of SEQ ID NOs:158, 68, 5, 58, 329, 120, 380, 342, 88, 166, 266, 51, 310, 91, 427, 22, 84, 269, 388, 155, 333, 215, 195, 419, 75, 125, 11, 251, 253, 337, 110, 222, 56, 324, 156, 7, 57, 233, 149, 363, 107, 193, 393, 265, 160, 41, 38, 90, 70, 85, 403, 304, 426, 240, 49, 294, 136, 150, 232, 10, 392, 89, 332, 290, 422, 291, 114, 309, 203, 362, 397, 334, 302, 179, 171, 53, 402, 315, 271, 218, 154, 243, 211, 180, 412, 300, 131, 71, 398, 289, 371, 118, 220, 82, 42, 430, 64, 144, 2, 205, 405, 318, 146, 314, 12, 416, 267, 105, 353, 296, 224, 165, 113, 345, 387, 61, 250, 59, 235, 382, 143, 361, 372, 199, 79, 116, 162, 322, 354, 391, 377, 255, 270, 373, 104, 400, 67, 167, 423, 188, 182, 106, 54, 326, 164, 307, 383, 260, 340, 357, 390, 161, 6, 316, 272, 338, 241, 367, 379, 40, 381, 231, 39, 256, 286, 8, 151, 399, 33, 254, 295, 141, 429, 65, 229, 259, 355, 298, 173, 371, 86, 45, 305, 127, 133, 200, 313, 370, 112, 226, 249, 80, 299, 196, 27, 308, 288, 349, 108, 311, 14, 130, 285, 207, 365, 275, 284, 96, 172, 76, 279, 413, 351, 202, 37, 74, 375, 360, 170, 147, 151, 306, 366, 217, 394, 192, 341, 352, 83, 157, 122, 350, 30, 25, 260, 238, 428, 278, 252, 395, 343, 325, 31, 386, 301, 317, 29, 407, 72, 283, 227, 191, 126, 132, 187, 94, 66, 109, 46, 212, 24, 69, 425, 1, 347, 197, 263, 273, 344, 181, 177, 356, 257, 148, 244, 13, 73, 420, 36, 236, 210, 43, 174, 121, 138, 87, 194, 389, 44, 396, 184, 408, 242, 152, 47, 268, 128, 230, 225, 431, 60, 206, 424, 378, 358, 262, 246, 98, 320, 117, 401, 404, 264, 34, 303, 369, 92, 277, 93, 293, 153, 142, 16, 359, 406, 425, 327, 321, 204, 384, 175, 331, 297, 410, 111, 209, 101, 335, 213, 234, 178, 124, 336, 414, 19, 319, 418, 376, 411, 421, 348, 81, 374, 140, 62, 20, 168, 129, 415, 312, 282, 370, 28, 214, 223, 364, 119, 95, 228, 339, 97, 9, 102, 276, 417, 346, 258, 328, 183, 208, 135, 23, 15, 185, 292, 287, 186, 201, 35, 239, 21, 368, 221, 115, 3, 52, 17, 409, 48, 190, 385, 63, 99, 330, 78, 159, 100, 145, 123, 245, 134, 198, 189, 139, 176, 169, 323, 4, 55, 77, 32, 274, 50, 281, 163, 219, 52, 237, 261, 216, 103, wherein an alteration above a predetermined threshold in said level of expression of said at least one polynucleotide sequence in said cell of the subject relative to a level of expression of said at least one polynucleotide sequence in a reference cell is indicative of the prognosis of the subject diagnosed with multiple sclerosis.
3-4. (canceled)
A probeset comprising a plurality of oligonucleotides and no more than 700 oligonucleotides wherein each of said plurality of oligonucleotides is capable of specifically recognizing at least one polynucleotide sequence selected from the group consisting of SEQ ID NOs:158, 68, 5, 58, 329, 120, 380, 342, 88, 166, 266, 51, 310, 91, 427, 22, 84, 269, 388, 155, 333, 215, 195, 419, 75, 125, 11, 251, 253, 337, 110, 222, 56, 324, 156, 7, 57, 233, 149, 363, 107, 193, 393, 265, 160, 41, 38, 90, 70, 85, 403, 304, 426, 240, 49, 294, 136, 150, 232, 10, 392, 89, 332, 290, 422, 291, 114, 309, 203, 362, 397, 334, 302, 179, 171, 53, 402, 315, 271, 218, 154, 243, 211, 180, 412, 300, 131, 71, 398, 289, 371, 118, 220, 82, 42, 430, 64, 144, 2, 205, 405, 318, 146, 314, 12, 416, 267, 105, 353, 296, 224, 165, 113, 345, 387, 61, 250, 59, 235, 382, 143, 361, 372, 199, 79, 116, 162, 322, 354, 391, 377, 255, 270, 373, 104, 400, 67, 167, 423, 188, 182, 106, 54, 326, 164, 307, 383, 260, 340, 357, 390, 161, 6, 316, 272, 338, 241, 367, 379, 40, 381, 231, 39, 256, 286, 8, 151, 399, 33, 254, 295, 141, 429, 65, 229, 259, 355, 298, 173, 371, 86, 45, 305, 127, 133, 200, 313, 370, 112, 226, 249, 80, 299, 196, 27, 308, 288, 349, 108, 311, 14, 130, 285, 207, 365, 275, 284, 96, 172, 76, 279, 413, 351, 202, 37, 74, 375, 360, 170, 147, 151, 306, 366, 217, 394, 192, 341, 352, 83, 157, 122, 350, 30, 25, 260, 238, 428, 278, 252, 395, 343, 325, 31, 386, 301, 317, 29, 407, 72, 283, 227, 191, 126, 132, 187, 94, 66, 109, 46, 212, 24, 69, 425, 1, 347, 197, 263, 273, 344, 181, 177, 356, 257, 148, 244, 13, 73, 420, 36, 236, 210, 43, 174, 121, 138, 87, 194, 389, 44, 396, 184, 408, 242, 152, 47, 268, 128, 230, 225, 431, 60, 206, 424, 378, 358, 262, 246, 98, 320, 117, 401, 404, 264, 34, 303, 369, 92, 277, 93, 293, 153, 142, 16, 359, 406, 425, 327, 321, 204, 384, 175, 331, 297, 410, 111, 209, 101, 335, 213, 234, 178, 124, 336, 414, 19, 319, 418, 376, 411, 421, 348, 81, 374, 140, 62, 20, 168, 129, 415, 312, 282, 370, 28, 214, 223, 364, 119, 95, 228, 339, 97, 9, 102, 276, 417, 346, 258, 328, 183, 208, 135, 23, 15, 185, 292, 287, 186, 201, 35, 239, 21, 368, 221, 115, 3, 52, 17, 409, 48, 190, 385, 63, 99, 330, 78, 159, 100, 145, 123, 245, 134, 198, 189, 139, 176, 169, 323, 4, 55, 77, 32, 274, 50, 281, 163, 219, 52, 237, 261, 216, 103.
The probeset of claim 3, wherein each of said isolated nucleic acid sequences or said plurality of oligonucleotides is bound to a solid support.
16-18. (canceled)
(canceled)
Dependencies are inferred from the claim text.