Device for generating alternative of normal brain database

A device for generating alternative of normal brain surface database to be used for diagnosing disease, based on brain bloodstream images of subjects including patients which show bloodstream associated value of each points of brain, the device comprising:

• means for normalizing bloodstream associated value at each point of each brain bloodstream image of subject based on bloodstream associated values of a part or whole of brain bloodstream image of the subject;
• means for spatially transforming each brain bloodstream image of subject in accordance with anatomical standard brain;
• means for generating brain surface bloodstream image of each subjects based on said anatomically transformed and normalized brain bloodstream images of subjects, said brain surface bloodstream image having surface bloodstream associated value of each surface points, said surface bloodstream associated value being selected as representative value of bloodstream associated values from brain surface to predetermined depth perpendicular to the brain surface;
• and
• means for generating the alternative of normal brain surface database by obtaining mean bloodstream associated value and standard deviation for each surface points based on generated brain surface bloodstream image of each subjects, said mean bloodstream associated value and standard deviation being obtained by calculating average of selected bloodstream associated values and standard deviations of the surface portion, said selected bloodstream associated values are selected from all bloodstream associated values of the surface portion by excluding at least the smallest value to m-th smallest.

A computer-readable recording medium storing program for generating alternative of normal brain database to be used for diagnosing brain disease based on brain status images of subjects including patients, the alternative of normal brain database showing normal status of each points of brain, the program comprising instructions for the steps of:

• normalizing status value at each point of each brain status image of subject based on status values of a part or whole of brain status image of the subject;
• spatially transforming each brain status image of subject in accordance with anatomical standard brain;
• rejecting status values presumed as indicating disease with regard to each points of brain to be used for diagnosing disease based on said anatomically transformed and normalized brain status images of subjects;
• and
• generating the alternative of normal brain database by obtaining at least mean status value for said each point of brain to be used for diagnosing disease based on said anatomically transformed and normalized brain status images of subjects in which said status values presumed as indicating disease are rejected.

A computer-readable recording medium storing program for generating alternative of normal brain surface database to be used for diagnosing disease, based on brain bloodstream images of subjects including patients which show bloodstream associated value of each points of brain, the program comprising instructions for the steps of:

• normalizing bloodstream associated value at each point of each brain bloodstream image of subject based on bloodstream associated values of a part or whole of brain bloodstream image of the subject;
• spatially transforming each brain bloodstream image of subject in accordance with anatomical standard brain;
• generating brain surface bloodstream image of each subjects based on said anatomically transformed and normalized brain bloodstream images of subjects, said brain surface bloodstream image having surface bloodstream associated value of each surface points, said surface bloodstream associated value being selected as representative value of bloodstream associated values from brain surface to predetermined depth perpendicular to the brain surface;
• and
• generating the alternative of normal brain surface database by obtaining mean bloodstream associated value and standard deviation for each surface points based on generated brain surface bloodstream image of each subjects, said mean bloodstream associated value and standard deviation being obtained by calculating average of selected bloodstream associated values and standard deviations of the surface portion, said selected bloodstream associated values are selected from all bloodstream associated values of the surface portion by excluding at least the smallest value to m-th smallest.

A method for generating alternative of normal brain database to be used for diagnosing brain disease based on brain status images of subjects including patients, the alternative of normal brain database showing normal status of each points of brain, the method comprising the steps of:

• normalizing status value at each point of each brain status image of subject based on status values of a part or whole of brain status image of the subject;
• spatially transforming each brain status image of subject in accordance with anatomical standard brain;
• rejecting status values presumed as indicating disease with regard to each points of brain to be used for diagnosing disease based on said anatomically transformed and normalized brain status images of subjects;
• and
• generating the alternative of normal brain database by obtaining at least mean status value for said each point of brain to be used for diagnosing disease based on said anatomically transformed and normalized brain status images of subjects in which said status values presumed as indicating disease are rejected.

A method for generating alternative of normal brain surface database to be used for diagnosing disease, based on brain bloodstream images of subjects including patients which show bloodstream associated value of each points of brain, the method comprising the steps of:

• normalizing bloodstream associated value at each point of each brain bloodstream image of subject based on bloodstream associated values of a part or whole of brain bloodstream image of the subject;
• spatially transforming each brain bloodstream image of subject in accordance with anatomical standard brain;
• generating brain surface bloodstream image of each subjects based on said anatomically transformed and normalized brain bloodstream images of subjects, said brain surface bloodstream image having surface bloodstream associated value of each surface points, said surface bloodstream associated value being selected as representative value of bloodstream associated values from brain surface to predetermined depth perpendicular to the brain surface;
• and
• generating the alternative of normal brain surface database by obtaining mean bloodstream associated value and standard deviation for each surface points based on generated brain surface bloodstream image of each subjects, said mean bloodstream associated value and standard deviation being obtained by calculating average of selected bloodstream associated values and standard deviations of the surface portion, said selected bloodstream associated values are selected from all bloodstream associated values of the surface portion by excluding at least the smallest value to m-th smallest.